Objective-Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established.Method-This was a case-control genetic association study of HTT CAG allele size in two discovery cohorts of individuals with major depressive disorder and comparison subjects without major depression as well as a replication cohort of individuals with major depression and comparison subjects without major depression.
These findings provide preliminary evidence for the concurrent validity of the DVPRS as a brief, multidimensional measure of pain interference that make it a practical tool for use in primary care settings to assess the impact of pain on daily functioning and monitor chronic pain over time.
For evidence-based practice to become a reality, its effects must be demonstrated clearly in the clinical situation. Practitioners must be sen to access, evaluate and apply research-based evidence in their day-to-day work. In this article, the author considers how this process could work in mental health nursing.
In this article, the author examines the complex balance between care and control in mental health nursing. He suggests that, without intervention from those leading the profession, the emphasis on control will undermine the therapeutic value of care.
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