The Battelle Critical Care Decontamination System™ (CCDS™) decontaminates N95 filtering facepiece respirators (FFRs) using vapor phase hydrogen peroxide (VPHP) for reuse when there is a critical supply shortage. The Battelle CCDS received an Emergency Use Authorization (EUA) from the US Food and Drug Administration (FDA) in March 2020. This research focused on evaluating the mechanical properties of the straps as an indicator of respirator fit. The objective was to characterize the load generated by the straps following up to 20 don/doff and decontamination cycles in Battelle's CCDS. In general, the measured loads at 50 and 100% strains after 20 cycles were similar (±15%) to the as-received controls. Qualitatively, reductions in the load may be associated with loss of elasticity in the straps, potentially reducing the ability to obtain a proper fit. However, small changes in strap elasticity may not affect the ability to obtain a proper fit given the potential for variation in strap length and positioning on the head. Regardless, prior to reusing a N95 respirator, it is important to complete a visual inspection to ensure it is not damaged, malformed, or soiled. If so, it is recommended to discard the respirator and use a different one. Similarly, the respirator should be discarded if the wearer cannot obtain a proper fit during the user seal check.
Decontamination of N95 filtering facepiece respirators (FFRs) is a crisis capacity strategy allowed when there are known shortages of FFRs. The application of moist heat is one decontamination method that has shown promise and is the approach approved in the Steris Steam Emergency Use Authorization (EUA). This effort examines the use of multicookers to apply moist heat, as they are available in retail stores and more affordable than methods requiring more sophisticated equipment. Four of five multicooker models examined met the acceptance criteria for the test and one model was selected for inactivation testing. Tests were performed on four different FFR models with SARS‐CoV‐2 suspended in culture media, simulated saliva or simulated lung fluid. Moist heat treatment reduced recoverable titres of SARS‐CoV‐2 virus to levels below the limit of detection in all tests. Furthermore, these four FFR models showed no loss in collection efficiency, inhalation resistance or visual damage after up to 10 decontamination cycles. Two (2) FFR models showed a slight change in strap elasticity (<9%). These data show that moist heat treatment using a multicooker is a viable option for FFR decontamination in a crisis capacity strategy.
Aims: Assess the feasibility of using light from artificial sun lamps to decontaminate N95 filtering facepiece respirators (FFRs) contaminated with SARS-CoV-2. Methods and Results: FFR coupons or whole FFRs contaminated with 5 log 10 TCID 50 (target concentration) SARS-CoV-2 in culture media, simulated saliva, or simulated lung fluid were dried for 1-2 h, then exposed to light from tanning and horticulture lamps to assess decontamination. Exposed coupons and whole FFRs showed SARS-CoV-2 inactivation for all matrices tested. Furthermore, FFRs still met performance specifications after five decontamination cycles. Conclusions: It is feasible that artificial sunlight from these sun lamps can be used to decontaminate FFRs provided the UV dose is sufficient and the light is unobstructed. Furthermore, decontamination can be performed up to five times without degrading FFR performance. Significance and Impact of the Study: This research shows a proof of principle that artificial sun lamps may be an option to decontaminate SARS-CoV-2 on N95 FFRs. UV doses required for inactivation to levels below detection ranged from 4 to 37Á8 J cm À2 depending on the light source, virus matrix and FFR type.
Coronary artery tortuosity (CAT) is an anatomical anomaly in which the coronary arteries contain kinks or coils. It is usually found incidentally in elderly patients with long-standing uncontrolled hypertension. This case illustrates a 58-year-old female marathon runner who was found to have CAT, originally presenting with chest pain, hypotension, presyncope, and a severe cramping sensation in her legs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.