Bulk transcriptome analysis Observations Validations Highlights Liver organoids from patients with BA exhibited aberrant morphology and disturbed apical-basal organization. Transcriptomic analysis of BA organoids revealed a shift from cholangiocyte to hepatocyte transcriptional signatures. Beta-amyloid accumulation was observed around the bile ducts in BA livers. Exposure to beta-amyloid induced aberrant morphology in control organoids. Beta-amyloid accumulation represents a novel finding with pathobiological implications and diagnostic potential for BA.
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