Intracameral cefuroxime and moxifloxacin reduced endophthalmitis rates compared with controls with minimal or no toxicity events at standard doses. Additionally, intracameral antibiotics alone may be as effective as intracameral plus topical antibiotics.

No abstract

A strategy for the synthesis of differentiated vicinal tertiary diols is described. The key step is a high-yielding, diastereoselective LaCl3·2LiCl-mediated addition of a Grignard or organolithium reagent to ketone 2a. The reaction is believed to proceed via a 1,3-chelated intermediate. One of the adducts has been transformed into a functionalized cyclopentenone resembling the core structure of pactamycin.

Patients are highly satisfied with their urinary condition after urethroplasty. Pain frequency in the bladder and the urethra significantly improves after urethroplasty; however, perineal pain intensity can worsen and become chronic after surgery in some patients.

INTRODUCTION AND OBJECTIVES: The Jackson PROMS have been validated to assess subjective outcome in patients undergoing penile and bulbar urethroplasty. The aim of this study was to evaluate the subjective outcomes in the various techniques used for bulbar urethroplasty (with and without buccal mucosal grafts; transecting and non-transecting) using the said PROM.METHODS: 189 of 232 (81.5%) patients undergoing excision and primary anastomosis (EPA, n-17), dorsal/ventral buccal graft augmentation (DVP, n¼126), non-transecting anastomotic (NTABU, n¼23) or augmented non-transecting anastomotic urethroplasty (ANTABU, n¼23) completed both pre-and post-operative (at 6 months) questionnaires between 2014 and 2016. Mean patient age was 43 years.RESULTS: The results are summarised in Table 1. All patients completed pre and post-op questionnaires for each treatment modality and parameter evaluated. There is a statistically significant lower improvement in LUTS score (p¼0.014;IC 95% 0.8 to 7.4) and perceived flow (p¼0.0037;IC 95% 0.3 to 1.5) with EPA compared to the other treatment modalities (globally as "non-transecting"). Nevertheless there was no significant difference in their overall health status (p¼0.82;IC 95% -8.4 to 10.6) and 100% of the respondents having had this procedure were satisfied or very satisfied with the outcome of their surgery. When comparing those having a graft augmentation (DVP + ANTABU) and those having an anastomotic procedure with no graft (EPA + NTABU), there was no statistically significant difference between the two for every parameter in the PROM.CONCLUSIONS: Overall the PROM seems to be very satisfactory but the results with EPA are clearly different. It may be because this is a different aetiology -external trauma -and because most of them presented with suprapubic catheters, both of which would alter their perception compared with that of patients with non-traumatic strictures. Use of a buccal graft has not been shown to be associated with a worse subjective outcome.