Nurse rostering is a complex scheduling problem that affects hospital personnel on a daily basis all over the world. The need for quality software solutions is acute for a number of reasons. In particular, it is very important to efficiently utilise time and effort, to evenly balance the workload among people and to attempt to satisfy personnel preferences. A high quality roster can lead to a more contented and thus more effective workforce.In this review, we discuss nurse rostering within the global personnel scheduling problem in healthcare. We begin by briefly discussing the review and overview papers that have appeared in the literature and by noting the role that nurse rostering plays within the wider context of longer term hospital personnel planning. The main body of the paper describes and critically evaluates solution approaches which span the interdisciplinary spectrum from operations research techniques to artificial intelligence methods. We conclude by drawing on the strengths and weaknesses of the literature to outline the key issues that need addressing in future nurse rostering research.
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Finding the most promising genes among large lists of candidate genes has been defined as the gene prioritization problem. It is a recurrent problem in genetics in which genetic conditions are reported to be associated with chromosomal regions. In the last decade, several different computational approaches have been developed to tackle this challenging task. In this study, we review 19 computational solutions for human gene prioritization that are freely accessible as web tools and illustrate their differences. We summarize the various biological problems to which they have been successfully applied. Ultimately, we describe several research directions that could increase the quality and applicability of the tools. In addition we developed a website (http://www.esat.kuleuven.be/gpp) containing detailed information about these and other tools, which is regularly updated. This review and the associated website constitute together a guide to help users select a gene prioritization strategy that suits best their needs.
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