Background: Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumour. The standard of care is surgical resection, followed by radiotherapy with concurrent and adjuvant temozolomide. In Latin America, there is scarcity of information about the incidence of GBM and even less data regarding outcomes. In this study, we describe the clinicopathologic features, management and outcomes of GBM patients. Methods: We describe a single-centre multidisciplinary team experience in managing GBM patients over an 11-year period (Jan 2005 to Dec 2016). Pathology was reviewed by the pathology collaborator and retrospective chart review performed for treatment and clinical outcomes. Results: We identified 74 patients (50 males) with diagnosis of GBM. Median age at diagnosis was 58 years (range 24-79 years), and median Karnofsky performance status was 80%. Forty-three (58.1%) went to gross total resection, 20 (27%) partial resection and 11 (14.9%) biopsy. Sixty-four (87%) patients received Stupp regimen. The median overall survival (OS) was 13.9 months (standard error (SE) 1.71; 95% confidence interval (CI), 10.56-17.23). In patients treated according to Stupp regimen, the progression-free survival (PFS) was 10 months (
Arch Argent Pediatr 2016;114(2):e91-e94 / e91Presentación de casos clínicos RESUMEN La cetoacidosis diabética en niños puede ser una causa de morbilidad grave y mortalidad, especialmente si no se reconoce en el momento del primer diagnóstico. Sin embargo, existen otras patologías que pueden aparentar una alteración metabólica de este tipo y pasarse por alto si no se tiene sospecha clínica. A continuación, se describe un caso clínico que presenta cetoacidosis hiperglicémica debido al contacto con organofosforado, en el cual fue necesario el uso de insulina en infusión continua para el control del trastorno metabólico, sin repercusiones después del alta. Palabras clave: compuestos organofosforados, acetilcolinesterasa, hiperglicemia, cetoacidosis, convulsiones.ABSTRACT Diabetic ketoacidosis in children causes serious morbidity and mortality, especially if it is not recognized on time in the initial diagnosis. However, there are other diseases that can appear to be a metabolic disorder of this kind and be ignored if it is not suspected. We present a clinical case with hyperglycemic ketoacidosis due to the contact with organophosphate; we had to use a continuous infusion of insulin to control the metabolic disorder without repercussions after the girl came home.
En el área industrial existe una variabilidad de tecnologías controladores con diversas características, dificultando de esta forma su intercomunicación e interoperabilidad, debido a esto se ha propuesto la tecnología OPC-UA como una alternativa que permite la intercomunicación entre controladores de diferentes fabricantes. El presente trabajo tuvo como objetivo el análisis del uso de esta tecnología para la intercomunicación de controladores industriales con diferentes protocolos de comunicación, el método utilizado fue a través del análisis de casos de estudios con diferentes características referentes a seguridades, cifrado y firma digital. Los resultados mostraron que el uso del sistema de comunicación OPC-UA redujo las complejidades de configuración ya que soporta sistemas abiertos, toleró cortafuegos y la configuración. Permitiendo la validación inmediata de variables desde el sistema SCADA hasta los controladores industriales sin previa configuración. Con esto se concluyó que la comunicación OPC-UA puede reemplazar eficazmente al sistema tradicional OPC.
<p>In April 2016, a Mw 7.8 earthquake struck the coast of Ecuador, causing major destruction in the cities located near the epicenter. Most of the residential buildings did not collapse but they experienced substantial damage of the non-structural components and some structural elements. The design for life safety and collapse prevention criteria were satisfied; however, the damage level prohibited their subsequent occupancy. As a result, all social activities of the affected cities cannot normalize until this infrastructure is reconstructed. In this paper, the Centinela building, a structure affected by the earthquake, is investigated to determine the damage level and retrofit alternatives. In addition, a risk assessment is conducted to predict the response of the building during future events, considering both the structural and non-structural components. In the future, these types of assessments may serve as a decision-making tool for government agencies and owners.</p>
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