Two studies addressed the normative aspects of attachments to mothers and fathers in middle childhood. Using both cross-sectional and longitudinal comparisons, we tested the hypothesis that children show no changes in perceptions of availability of attachment figures across the later middle childhood years, but do utilize attachment figures less at older ages. The first study included a cross-sectional comparison of third and sixth graders, and the second study was a follow-up on the third graders when they were in fifth grade. Both studies suggested a decline in utilization, but not in perceptions of availability of attachment figures within the later middle childhood years. Study 1 also demonstrated that children turn to parents to meet attachment needs, and peers to meet companionship needs. Study 2 examined individual differences in attachment by exploring how changes in attachment to mothers from third to fifth grade were related to children's social adjustment at fifth grade. Increases in perceptions of availability forecast better emotional and behavioral regulation at fifth grade. Changes in utilization of attachment figures showed both linear and nonlinear relations to regulation. Bowlby's (1982Bowlby's ( , 1979 theory of attachment has provided one framework for conceptualizing the nature and significance of parent-child bonds. Bowlby's theory is broad in scope, addressing both normative patterns of change as well as the precursors to and sequelae of qualitative differences in attachment. To date, most of the research on attachment has been focused on individual differences and, consequently, less is known about normative changes in attachment, particularly beyond infancy.The main goal of the present studies was to examine whether there are changes in children's perceptions of their utilization of attachment figures in the later middle childhood years. In addition, Study 1 examined whether children at this age direct attachment behavior to parents or to peers, and Study 2 examined how changes in attachment are related to children's later social and emotional development.

Background Sub-Saharan Africa carries the highest HIV burden globally. It is important to understand how interventions cost-effectively fit within guidelines and implementation plans, especially in low- and middle-income settings. We reviewed the evidence from economic evaluations of HIV prevention interventions in sub-Saharan Africa to help inform the allocation of limited resources. Methods We searched PubMed, Web of Science, Econ-Lit, Embase, and African Index Medicus. We included studies published between January 2009 and December 2018 reporting cost-effectiveness estimates of HIV prevention interventions. We extracted health outcomes and cost-effectiveness ratios (CERs) and evaluated study quality using the CHEERS checklist. Findings 60 studies met the full inclusion criteria. Prevention of mother-to-child transmission interventions had the lowest median CERs ($1144/HIV infection averted and $191/DALY averted), while pre-exposure prophylaxis interventions had the highest ($13,267/HIA and $799/DALY averted). Structural interventions (partner notification, cash transfer programs) have similar CERs ($3576/HIA and $392/DALY averted) to male circumcision ($2965/HIA) and were more favourable to treatment-as-prevention interventions ($7903/HIA and $890/DALY averted). Most interventions showed increased cost-effectiveness when prioritizing specific target groups based on age and risk. Interpretation The presented cost-effectiveness information can aid policy makers and other stakeholders as they develop guidelines and programming for HIV prevention plans in resource-constrained settings.

Retinal arbors in the tectum of living adult goldfish were imaged to determine whether the structural remodelling and refinement that occurs during development continues in adulthood. Individual optic fibers were labelled by making small injections of the lipophilic fluorescent dye DiI into ventral retina and viewing the exposed tectum through a fluorescence microscope equipped with a cooled CCD camera. Arbors were imaged in the living fish every 30-60 minutes for up to 7 hours. Normal adult goldfish showed no evidence of arbor remodelling during this period, though dynamic movements of varicosities present along axon segments were observed. For comparison, regenerating optic fibers were similarly imaged in fish that had undergone optic nerve crush 2-6 weeks previously. In these fish, dynamic structural changes were seen, including branch remodelling, extension and retraction of growth cones, and movement of varicosities.

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Despite the fact that Asians constituted a sizeable proportion of those exposed to the World Trade Center attack on September 11, 2001 due to its proximity to Chinatown and many South Asians working in the nearby buildings, no study had focused on examining the mental health impact of the attack in this group. Based on data collected by the World Trade Center Health Registry from a sample of 4721 Asians 2-3 years after the disaster, this study provides a baseline investigation for the prevalence and the risk and protective factors for PTSD among Asian Americans directly exposed to the attack and compared this population against 42,862 non-Hispanic Whites. We found that Asians had a higher prevalence of PTSD compared to Whites (14.6 vs 11.7%). "Race-specific factors" significantly associated to PTSD in the multivariate analyses were noted among sociodemographics: higher education was protective for Whites but a risk factor for Asians; being employed was protective for Whites but had no effect for Asians; and being an immigrant was a risk factor for Whites but had no effect for Asians. However, income was a protective factor for both races. Other "universal factors" significantly increased the odds of PTSD symptoms but showed no racial differences, including exposure to the disaster and the presence of lower respiratory symptoms which intensified odds of PTSD by the greatest magnitude (3.6-3.9 times). Targeted effort to reach out to Asians is essential for prevention and follow up treatment given this group's striking history of underutilization of mental health services.