Six novel sesquiterpenes, piptocarphins A-F, were isolated from Piptocarpha chontalensis Pall Their structures were elucidated as a series of closely related germacranolide sesquiterpene lactones possessing an unusual conjugated enol lactone and an intramolecular hemiketal functionality on the basis of an extensive spectral analysis. All compounds exhibited cytotoxic activity against the 9KB human nasopharynx carcinoma cells. Piptocarphins A and C also showed borderline activity in the P-388 lymphoid leukemia system.

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Neue Sesquiterpene, die Piptocarphine A ‐ F, werden aus Piptocarpha chontalensis Pall isoliert und ihre Strukturen im Sinne von (I) aufgeklärt.