An octogenarian female patient, admitted for heart failure secondary to severe aortic stenosis decompensated by atrial fibrillation, with a high ventricular response. When clinically compensated, she was discharged on oral anticoagulation with a direct-acting anticoagulant, for outpatient scheduling of a transcatheter implantation of aortic valve bioprosthesis. She was readmitted early due to low digestive bleeding secondary to locally advanced stenosing colon cancer. After discussion with the Heart Team and the oncology team, a transcatheter implantation of aortic valve bioprosthesis was the treatment chosen, followed by a colectomy 1 week later. She evolved clinically stable with early discharge from hospital, on oral anticoagulation with a direct-acting anticoagulant. In the 6-month follow-up, she remained asymptomatic from the cardiovascular point of view and with no recurrence of the low digestive tract bleeding.
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