Objective: Peptic ulcer causes lesions in the stomach and oesophagus. The present work is aimed to develop the effervescent granules of Ranitidine Hydrochloride to relieve the pain instantly.: Effervescent Materials and methods granules were prepared by dry granulation technique using disodium citrate, sodium saccharin, polyvinyl pyrrolidine, glycine, sodium benzoate, sodium bicarbonate. The prepared granules were evaluated for angle of repose, bulk and tapped density, carr's index and hausner's ratio, in-vitro drug release studies and DSC.The angle of repose for Results: formulations F1-F6 was obtained in the range of 32.38°±0.34 to 37.65°±0.53 which indicates the passible flow property of the formulation. Bulk density and Tapped density for formulations F1-F6 was obtained in the range of 0.42 ± 0.01 to 0.46 ±0.02 and 0.51±0.02 to 0.58±0.02 respectively. The Carr's Index and Hausners Ratio for the formulations F1-F6 was obtained in a range of 15.85±2.97 to 22.4 ± 2.88 and 1.256±0.05 to 1.196±0.04 which indicates good flow property of the given formulation. Percentage release of the drug for the formulations F1-F6 was obtained in a range of 50% to 91%.Among all formulations F4 formulation has highest amount of drug release compared to other Conclusion: formulations. Hence it was considered as promising formulation for further studies. DSC of F4 formulation was found be at 184.5 which indicates that there is no incompatibility between the drug and excipients.
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