Patients with VKC or AC were at increased risk of KC. They had more severe KC and should be closely followed up and intensively treated.

No abstract

KC is an asymmetric disease, and the degree of asymmetry is associated with disease severity. The analysis of intereye asymmetry should be performed along with unilateral evaluation in the screening of KC.

We suggest that patients with more family members with KC should be subject to screening to identify early disease.

Our findings suggest that KC is more severe in pediatrics, hence the fact that they should be closely monitored and intensively treated.