Study DesignClinical trial study.PurposeThe aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury.Overview of LiteratureThe prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events.MethodsThis clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy.ResultsThe severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods.ConclusionsWe observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
Objective: Acute spinal cord injury (ASCI) is among the most common and important disorders in the field of neurosurgery and causes sensory, motor, urinary tract impairment or combination of them. Many pharmacological agents, like Erythropoietin, are used to reduce secondary damage after the primary insult and try to preserve nerve tissue. Materials and Methods: In the present clinical trial, 60 patients with ASCI in the Frankel classification, the category A to C, and the selection of matched Frankel class into two groups A and B (each group consisted of 30 patients) were participated. Group A underwent the conventional treatment received methylprednisolone and erythropoietin. In the first day of hospitalization and 4 day after admission the amount of Malondialdehyde (MDA) and Total Antioxidant Capacity(TAC) evaluated and compared to group B(that received conventional treatment such as methylprednisolone). Results: In the first day of hospitalization the average amount of MDA was 5.37 nmol/ml in the case group and 4.76 nmol/ml in the control. Four days after admission average MDA decreased to 3.83 nmol/ml in case group and 3.98nmol/ml in the control. TAC in the first day of hospitalization was 1.37 nmol/ml in the case group and 1.25 nmol/ml in the control group. In day 4 after admission the average TAC in case group decreased to 1.08 nmol/ml and 1.14 nmol/ml in the control. Conclusion: There is a significant correlation between the reduction of oxidation metabolites in the case and control group. This indicates that Erythropoietin and pro-inflammatory cytokines by reducing metabolites and inflammation can consequently reduce spinal cord injury.
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