Aluminum phosphide (ALP) poisoning is one of the major causes of suicidal deaths. Toxicity by ALP is caused by the liberation of phosphine gas, which rapidly causes cell hypoxia due to inhibition of oxidative phosphorylation, leading to circulatory failure. Treatment of ALP toxicity is mainly supportive as there is no specific antidote. We recently managed 7 cases of ALP poisoning with severe hemodynamic effects. Patients were treated with supportive measures including gastric lavage with diluted potassium permanganate, coconut oil and sodium-bicarbonate first person account should be avoided in a scientific paper. Intravenous magnesium sulfate, proper hemodynamic monitoring and vasopressors. Four out of 7 survived thus suggesting a role of such supportive measures in the absence of specific antidote for ALP poisoning.
Potassium permanganate (KMnO4) is rarely used for suicidal attempt. Its ingestion can lead to local as well as systemic toxicities due to coagulation necrosis and damage, caused by free radicals of permanganate. We recently managed a case of suicidal ingestion of KMnO4 in a lethal dose. She had significant narrowing of upper airway leading to difficult intubation as well as hepatic dysfunction and coagulopathy as systemic manifestation. We suggest to keep ourselves ready to handle difficult airway with the aid of fiber optic bronchoscope or surgical airway management in such patients. Upper gastrointestinal (GI) endoscopy should be done at the earliest to determine the extent of upper GI injury and further nutrition planning.
Plasmodium malariae is one of the causative agents of the deadly disease, malaria. From past few years, investigators have been vigorously involved in searching for an effective cure for this disease. However, the available drugs have not yet proven to be quite effi cient in its eradication primarily because of the advanced rate of mutation of the parasite. The present study is directed towards fi nding an inhibitor against plasmepsin II, one of the aspartic protease encoded by the malarial parasite, which is essential in degrading the host hemoglobin. The structure of the biological target was used to predict candidate drugs that could bind with high affi nity and selectivity to the target. The docking behaviour of target protein (2BJU) was studied in order to fi nd out the binding sites for the inhibitor on the protein molecule. The binding pocket that was selected had Phe84 and Thr341 as their active residues, depending upon which few ligand molecules were examined. Subsequently one of the ligand exhibited the best binding properties and the drug likeliness studies were carried out. Based on these studies, it could be inferred that the selected ligand could act as a potential drug candidate and thus, could also be considered for further studies.
The frequent traffic jams at major junctions call for an efficient traffic management system in place. The resulting wastage of time and increase in pollution levels can be eliminated on a city-wide scale by these systems. The image sequences from a camera are analyzed using various edge detection and object counting methods to obtain the most efficient technique. Subsequently, the number of vehicles at the intersection is evaluated and traffic is efficiently managed.
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