The present study focused on the preparation of form-stable composites of 1-tetradecanoic acid (TDA)/titanium dioxide (TiO 2) powder via a facile impregnation method. The use of powdered TiO 2 as porous material and thermal conductivity enhancer for TDA is a novel attempt. The morphological, chemical, and crystalline properties of form-stable composite PCMs (Fs-CPCMs), containing different amounts of TiO 2 , were characterized using field emission scanning electron microscope, Fourier transform infrared spectroscopy, and X-ray diffraction techniques. The finding supports that the produced composites were chemically and structurally stable. The latent heat storage (LHS) properties of composites were obtained from differential scanning calorimeter instrument, and the findings revealed that the Fs-CPCM with 50 mass% TDA has a melting temperature of 52.04 C and a considerably good LHS capacity of 97.75 J/g. The thermal conductivity of TDA was increased remarkably by the addition of TiO 2 micro particles. The results obtained from thermogravimetric analysis and thermal cycling test exhibited that the Fs-CPCM, containing 50 mass% TiO 2 , possesses great thermal degradation durability, cycling chemical stability, and thermal reliability. This composite PCM can be very well used for passive thermal management of electronic devices, automotive components, photovoltaic thermal hybrid designs, solar air/water heating systems, etc.

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Introduction: Hyperbaric bupivacaine is commonly used as local anaesthetic for administering spinal anaesthesia. Spinal anaesthesia using local anaesthetic alone is associated with relatively short duration of action. Adjuvants are added to improve the quality, to accelerate the onset of action, prolong analgesia and to overcome the problems of spinal anaesthesia. Hypothesis: To compare the effect of intrathecal 0.5% Hyperbaric Bupivacaine 16mg over 0.5% Hyperbaric Bupivacaine 16mg + 5μg Dexmedetomidine with respect to Haemodynamic changes. Sample Size: We conducted the study on 60 patients over a period of one year and six months from 1 March 2016 to 31 August 2017. Results: Our study show that supplementation of spinal bupivacaine with 5 microgram dexmedetomidine resulted in stable hemodynamics. There was no significant decrease in the mean heart rate in dexmedetomidine group when compared to bupivacaine alone group. Conclusion: Our study showed that there was no significant decrease in the mean heart rate in dexmedetomidine group when compared to bupivacaine alone group.

BACKGROUND Several adjuvants have been tried along with local anaesthetic in spinal anaesthesia for prolonging the duration of analgesia . Intrathecal midazolam produces anti-nociception and potentiates the effect of local anaesthetics. The aim of this study is to study the comparison between intrathecal bupivacaine and bupivacaine with midazolam with spinal anaesthesia. MATERIALS AND METHODSThis is a comparative, randomised, double-blinded study of 90 patients within the age group of 18 -60 years with ASA status I or II, undergoing various lower abdominal surgical procedures. They were randomly allocated to one of the two groups, each containing 45 patients as follows: The B group receiving 2 mL of 0.5% hyperbaric bupivacaine (10 mg) and 1 mL of 0.9% saline intrathecally; the BM group receiving 2 mL of 0.5% hyperbaric bupivacaine (10 mg) with 1 mL (1 mg) of preservative-free midazolam. The onset, duration of sensory/ motor block, the time to achieve maximum sensory block and the level of block, time for first rescue analgesia, sedation score, quality of anaesthesia and side effects were noted. RESULTSThere was no significant difference in the demographic distribution of the patients. There was no statistically significant difference in the onset of the sensory block (p-value > 0.05) and time to achieve maximum level of sensory block in both groups (p-value > 0.05). Mean duration of sensory block or effective analgesia in group BM was 330.88 ± 16.36 minutes, while that in group B was 273.68 ± 15.69 minutes, which was statistically significant (p-value < 0.05). There was no statistically significant difference between both the groups with respect to motor block and quality of anaesthesia. The sedation score was comparable in both groups. The side effect profiles in both groups were also comparable. CONCLUSIONThe addition of 1 mg preservative-free midazolam to 0.5% hyperbaric bupivacaine prolongs the duration of effective analgesia as compared to bupivacaine alone and delays the need for postoperative rescue analgesics without affecting the onset of block and without increasing the risk of side effects. Spinal anaesthesia with bupivacaine is routinely administered for lower abdominal surgeries with adequate motor blockage, additionally providing effective pain relief in the initial post-operative period due to its long duration of action. 1 However, the Cardiovascular Collapse/ Central Nervous System (CC/CNS) ratio of bupivacaine is narrow (2.7) with a higher propensity of irreversible cardiovascular collapse. 1 'Financial or Other Competing Interest': None. Submission 22-11-2017, Peer Review 16-12-2017, Acceptance 22-12-2017, Published 08-01-2018. Corresponding Author: Dr. Partha Pratim Deka, Meridiyen Apartments, Apt. No. 409, Deralakatte, Yenepoya Medical College, Mangalore-575018, Karnataka, India. E-mail: dr.parthadeka@live.in DOI: 10.14260/jemds/2018 Therefore, in order to minimise the dose of bupivacaine and to reduce its side effects the use of an adjuvant that would prolong its duration...