Background: Antibacterial agents have always been the part and parcel in the treatment of periodontal infection. One such known agent is Active Leptospermum Honey (ALH) which has been the most studied species of medical grade honey used for the treatment of wounds and burns. Therefore, this study revolves around evaluating the efficacy of active leptospermum honey as a local drug delivery (LDD) agent on probing pocket depth (PPD), relative attachment level (RAL), and periodontal pocket pH. Materials and Methods: Based on the study's inclusion and exclusion criteria, a total of 100 sites with probing pocket depth of ≥ 5mm in posterior region will be selected. The sites will be grouped as: Test Group: 50 sites, Control Group: 50 sites, following the assessment of baseline clinical and biochemical parameters. At the baseline appointment, each patient received full mouth scaling and root planning (SRP). They were called back after 48 hours. Following the assessment of biochemical parameters by using pH test paper strips, MEDIHONEY® was placed as a local drug delivery (LDD) agent in test sites. In control sites only SRP was done. Patients were recalled after 30 days following LDD to reassess only gingival index, plaque index and biochemical parameters. Patients were recalled at 90 days following LDD for the reassessment of all clinical and biochemical parameters. Results: Plaque and gingival inflammation reduced in both groups but test group showed more reduction. Pocket depths were reduced significantly in test site. There was significant pH reduction in test sites. Clinical attachment level was also seen to be improved in the sites which were tested. Conclusion: When administered locally, Active Leptospermum Honey demonstrated lessening of PPD, gingival index (GI), and plaque index (PI), as well as higher levels of clinical attachment (CA).
Purpose:Gastritis leadind to G.I.ulcers is a very prevalent metabolic and life style disorder. Many a times it is condition which arise due to various medications like NSAID's. Drugs effective in Ulcer protection is the need of the hour. Medications such as sucralfate in conventional system do work but in higher dose and with limitations. Thus, present study has been carried out, to evaluate efficacy of Varatika bhasma in ulcer protective activity with standard control as Sucralfate in aspirin induced ulcer.Method:Varatika bhasma was prepared by shodhana with kanji, bhaavana with kumari swarasa and subjecting to gajaputa. Further it was analyzed and used for experimental study. Winstar strain albino rats of either sex was taken in 3 groups with 6 rats in each group. Control group with food and water, standard with sucralfate and test with varatika bhasma was given for 6 days. on 7th day ulcer was induced with aspirin. later rats were sacrificed to cut open the stomach and to study the ulcer index and histopathology.Result:When compared to Sucralfate for ulcer protective effect, Varatika Bhasma shows significant result in lower doses. (Sucralfate 1 gm 6 hourly and Varatika Bhasma 250 mg twice daily). In ulcer index and histopathology studies, there were less / no ulcers found in the group treated with Varatika Bhasma in comparison with Sucralfate and Control group.Conclusion:For the ulcer protection, Varatika Bhasma provides better and promising result when compared to Sucralfate. This also cuts the cost of medication and time constrain for the administration of the medicine.
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