The results of this study can be used to provide a better anatomical understanding of the area, which is necessary for endoscopic skull base surgeons.

BackgroundSeveral researches have recommended vitamin D possible health benefits on diabetic complications development, but a few number of studies have been accomplished on the molecular and cellular mechanisms. Certain cellular pathways modification and also some transcription factors activation may protect cells from hyperglycemia condition induced damages. This study purpose was to determine the vitamin D supplementation effect on some key factors [advanced glycation end products (AGEs) signaling pathway] that were involved in the diabetic complications occurrence and progression for type-2 diabetes participants.Methodology48 type-2 diabetic patients (T2DM) randomly divided into two groups (n = 24 per group), receiving: 100-µg vitamin D or placebo for 3 months. At this study beginning and the end, the receptor expression for advanced glycation end products (RAGE) and glyoxalase I (GLO1) enzyme from peripheral blood mononuclear cells (PBMCs) and AGEs and tumor necrosis factor-α (TNF-α) serum levels were measured by the use of real-time PCR and ELISA methods, respectively.ResultsThis study results demonstrated that vitamin D supplementation could down-regulate RAGE mRNA [fold change = 0.72 in vitamin D vs. 0.95 in placebo) P = 0.001)]. In addition, no significant changes were observed for GLO1 enzyme expression (P = 0.06). This study results also indicated that vitamin D serum level significantly increased in vitamin D group (P < 0.001). Moreover, AGES and TNF-α serum levels significantly reduced in vitamin D group, but they were remained unchanged in the placebo group.ConclusionIn conclusion, vascular complications are more frequent in diabetic patients, and vitamin D treatment may prevent or delay the complications onset in these patients by AGEs serum level and RAGE gene expression reducing.Trial registration NCT03008057. Registered December 2016

Objective: Recent trial studies have found that resveratrol supplementation beneficially reduces oxidative stress marker, but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of resveratrol supplementation on oxidative stress parameters. Methods: We searched databases of Pubmed, Scopus and Cochrane Library up to December 2018 with no language restriction. Studies were reviewed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane handbook. To compare the effects of resveratrol with placebo, weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled based on the random-effects model. Results: Among sixteen clinical trials, we found that resveratrol supplementation increased GPx serum levels significantly (WMD: 18.61; 95% CI: 8.70 to 28.52; P<0.001) but had no significant effect on SOD concentrations (WMD: 1.01; 95% CI: -0.72 to 2.74; P= 0.25), MDA serum levels (WMD: -1.43; 95% CI: -3.46 to 0.61; P = 0.17) and TAC (WMD: -0.09; 95% CI: -0.29 to 0.11; P = 0.36) compared to placebo. Finally, we observed that resveratrol supplementation may not have a clinically significant effect on oxidative stress. Conclusion: However, the number of human trials is limited in this context, and further large prospective clinical trials are needed to confirm the effect of resveratrol supplement on oxidative stress markers.

OBJECTIVE:Tinnitus in one of the most common complaints of patients with acoustic neurinoma, which could lead to early diagnosis. Because postoperative tinnitus can have a profound effect on patients' quality of life, candidates for surgery should be thoroughly informed about the possible effect of the operation on their tinnitus status. Questionnaires were the only source of information for tinnitus evaluation in previous studies, most of which were retrospective. MATERIALS and METHODS:Twelve patients with unilateral tinnitus and hearing loss and definite diagnosis of acoustic neurinoma were operated via translabyrithine tumour resection. One week before and 3 months after complete translabyrinthine removal of tumour, tinnitus evaluation test was performed and pitch match of tinnitus and loudness match of tinnitus were measured. Then patients were asked to complete two Persian validated questionnaires, Tinnitus Handicap Inventory-Persian and Tinnitus Questionnaire-Persian. RESULTS:Psychoacoustic and psychometric aspects were improved in three patients, did not change in one patient, and worsened in one patient. In three patients, tinnitus disappeared and in four patients without preoperative tinnitus, it did not occur. CONCLUSION:Partial improvement in postoperative tinnitus was seen but prediction about tinnitus after surgery is not possible yet. Nonetheless, postoperative tinnitus is not bothersome and does not affect patients' lives.