The overwhelming majority of patients eligible for HER2-targeted therapy in our institution are unable to receive it because of financial constraints and limited access to health insurance. There is a higher fraction of patients with the triple negative phenotype compared to the Western population.
Tumors of facial skin are common in upper part of central subunit of face. Defects after resection require a flap, which is pliable, thin, and has a good colour match. Among the various local flaps available paramedian forehead flap is a good option. Patients and methods: Patients reconstructed with paramedian forehead flap during the period from January 2015 to March 2020 were included in the study. Data regarding the demographic, clinical characteristics, and treatment details was recorded, and analyzed for postoperative complications and cosmetic outcomes. Results: Paramedian forehead flap reconstruction was performed in 37 patients who were resected for tumor involving upper central subunit of face. Median age of patients was 57 years. Male to female ratio was 1.4:1. All tumors were resected with a negative margin. Nodal disease was managed by superficial parotidectomy only (4/ 37), superficial parotidectomy along with supra-omohyoid neck dissection (6/37) and modified neck dissection (1/37). In five patients additional buccal mucosa graft was used to reconstruct conjunctiva. Additional flaps were required in two patients in whom nasolabial and mustarde flaps were used. Partial flap loss occurred in one patient. There was no major flap loss. Surgical site infection developed in only one patient, who had partial flap loss. On subjective assessment, nearly 60% patients described their appearance as good. Conclusion: Facial reconstruction in area of dorsum of nose and medial aspect of both eyelids using paramedian forehead flaps is a simple and quick procedure.
A man in his mid-50s presented with heaviness in the right lower abdomen for the last three months. Ultrasonography (USG) showed an intra-abdominal mass in the right iliac fossa. Contrast-enhanced CT (CECT) revealed a well-defined circumscribed mass near the ileocaecal junction, with a hypodense center, surrounded by a hyperdense periphery and well-defined capsule. A lower midline laparotomy was performed. Intraoperatively, a white, firm, smooth ball-like mass was found, lying freely in the abdomen. Histopathology revealed fatty tissues surrounded by a calcified shell, which was further surrounded by proteinaceous material. Such peritoneal loose bodies (PLBs) are free masses in the abdomen, with variable sizes. These are asymptomatic, unless they compress any nearby viscera, as was in our case. The objective of this case report is to make surgeons and radiologists aware of this rare entity, which can be a source of confusion in a case of mass in the abdomen.
The blockchain typically described as a decentralized system in which transactional or ancient statistics are recorded, stored, and maintained throughout a peer-to-peer community of personal computers referred to as nodes. Counterfeit drugs are one consequence of such limitations within existing supply chains, which not only has serious adverse impact on human health but also causes severe economic loss to the healthcare industry. Blockchain technology has gained tremendous attention, with an escalating hobby in a plethora of several applications like safe and relaxed healthcare records management. Similarly, blockchain is reforming the traditional healthcare practices to an extra reliable means, in phrases of powerful prognosis and treatment through safe and cosy facts sharing using SHA Hash Generation Algorithm. Within the future, blockchain will be an era that can probably assist in personalized, authentic, and at ease healthcare by means of merging the entire actual-time scientific information of a patient’s fitness and offering it in an up to date cosy healthcare setup. In this paper, we evaluation each the present and modern day trends inside the subject of healthcare with the aid of imposing blockchain as a model. We also talk the packages of blockchain, at the side of the demanding situations confronted and destiny views. The proposed system executed blockchain implementation in distributed computing surroundings and it gives the automated restoration of invalid chain by using Consensus and Mining Algorithm. In this system, we present a Custom blockchain-based approach leveraging smart contracts and decentralized off-chain storage for efficient product traceability in the healthcare supply chain. The smart contract guarantees data provenance, eliminates the need for intermediaries and provides a secure, immutable history of transactions to all stakeholders. We present the system architecture and detailed algorithms that govern the working principles of our proposed solution. We perform testing and validation, and present cost and security analysis of the system to evaluate its effectiveness to enhance traceability within pharmaceutical supply chains.
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