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The simultaneous occurrence of primary brain tumors of different histological type in same patient is very rare. Most of these tumors arise after cranial radiotherapy or in association with familial tumor syndromes and very few simultaneously occurring cases have been reported previously. We describe an additional case with simultaneous meningioma and glioblastoma multiforme at different intracranial location, without past cranial radiotherapy or phacomatosis in a 59-year-old female patient. Clinical manifestations, characteristic imaging findings, and possible mechanisms, as well as the treatment results are discussed and compared with previously reported cases.