Background. p27 BBP is a regulator of ribosome assembly and an essential nuclear and cytoplasmic component of eukaryotes.Methods. We investigated the immunochemical distribution of p27 BBP in head and neck carcinomas, in the associated normal mucosa, and in regional lymph nodes.Results. p27 BBP is detectable in mucosal cells but is overexpressed in carcinomas, highly concentrated in large polymorphous nucleoli, and even larger and more evident in lymph node metastatic foci. Western blotting confirms increased p27 BBP in carcinomas versus normal mucosa and also in metastatic versus normal lymph nodes. The overexpression of p27 BBP corresponds to mRNA upregulation in carcinomas. Unexpectedly, a 52-kDa band specifically reacting with antibodies to p27 BBP was observed in several carcinomas.Conclusions. p27 BBP alterations are common events in the transition to malignancy and are probably involved in squamous carcinoma progression. Immune reagents raised to p27 BBP may provide additional diagnostic tools for surgical pathology of tumor boundaries and lymph nodes. The 52-kDa band may represent an abnormal form of p27 BBP expressed by transformed airway epithelia.
Leiomyosarcoma involving the larynx is extremely rare and may be difficult to diagnose. Because of the rarity of this tumor, little information exists on its long-term follow-up and optimal management. We present a review of the literature and report on a patient with leiomyosarcoma of the larynx treated with surgery and postoperative irradiation. In addition, the diagnosis and treatment of leiomyosarcoma are discussed. At six months' follow-up the patient showed no signs of local recurrence but had developed metastases to both lungs.
The indications for combined treatment should be correlated with the prognostic factors to increase the survival rate of patients with stage III and IV laryngeal carcinoma.
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