The outcome of uncomplicated cases with B19 infection is good. In the presence of hydrops prognosis was very poor. It seems therefore logical to attempt to pick up this ominous signs early.

Congenital CMV infection does not seem to be associated with a higher incidence of SGA, and long-term outcomes do not seem to be affected by isolated impaired fetal growth.

Two placentas in singleton pregnancy with fused umbilical cord which has its own placental insertion site forming 3-vessel cord at fetal end is an extremely rare case. This present case describes two placentas with fused umbilical cord with an episode of vanishing twin syndrome and there seems to be a strong relationship between these two events. Therefore, as far as we know, this is the first case in the world which describes two placentas with fused umbilical cord related to vanishing twin syndrome. A 37-year-old woman, gravid 0, para 0, visited ER with an episode of vaginal bleeding without pelvic cramps at 8 weeks and 5 days of gestation and repeated ultrasonic exams revealed reabsorption of vanishing twin and two separate placentas on anterior and posterior body of uterus. At 40 weeks and 4 days, the patient delivered a viable female infant weighing 3900 g via Cesarean section and postpartum examination of the placentas and membranes confirmed two placentas with fused umbilical cord. Two placentas were almost equal in size and main placental disc cord had 2 arteries with one vein (3 vessel-cord) whereas side placental disc cord had one artery with one vein (2 vessel-cord). Several hypothesis including placenta abnormalities after IVF-ET procedure, succenturiate lobes and fetus-in-fetu were proposed.Supporting information can be found in the online version of this abstract. P01.02May the Silver-Russell syndrome be suspected in utero by ultrasound? Intrauterine growth retardation (IUGR) can be a significant feature of many recognized genetic syndromes including Silver-Russell syndrome. We describe a case of IUGR, first ascertained at 24 wks, when measurements were about 4 weeks less than gestational age: BPD 58 mm (34 • percentile), CC 220 mm (10 • percentile) and CA, FL and HL < 5 th percentile. Amniocentesis performed for advanced maternal age at 15 wks showed a normal karyotype. At 20 wga mild cerebral ventricular dilation was ascertained. No additional CNS anomalies were noted. The cardiovascular, urinary and gastrointestinal systems were normal as well as amniotic fluid volume and fetal movements. The disproportion between cephalic and body length growth was more evident after 28 wks. Uteroplacental insufficiency was excluded by serial Doppler measurements. Considering the ultrasound findings, the clinical geneticist proposed the array-CGH analysis on stored fetal DNA.However, no genomic rearrangements were identified. At 38 wks, caesarean section for breech presentation was performed. Birth weight was 1520 g (< 3 • percentile), OFC was 33 cm (25 • -50 • percentile) and a dysmetria between the length measured on the right and left side was noted (36 cm versus 37 cm; 3 • percentile). At evaluation, triangular face, posteriorly rotated ears with uplifted lobe, low anterior hairline, single palmar crease on the left hand and hypospadia were evidenced and a SilverRussell syndrome diagnosis was proposed. The genetic analysis identified 11p15.5 hypomethylation in the patient DNA, confirming the clinical diagno...

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