As the most common form of skin cancer, basal cell carcinoma (BCC) is typified by locally infiltrative growth and a very low risk of metastasis. On occasion, however, this otherwise indolent neoplasm may behave aggressively, demonstrating deep tissue invasion and a high rate of postsurgical recurrence. The pathogenesis and determinants of such tenacious growth are not completely understood. Only 1% of all BCC's achieve the status of 'giant', as defined in 1988 by the American Joint Committee on Cancer. In this article, the authors provide a comprehensive review of the scientific literature on giant basal cell carcinoma (GBCC) of the skin and report their experience with this rare tumour subtype.

The aim is to emphasize the notions: determinant indicator and predictor of risk factors for periodontal pathologies, and to show the interconnection logic, analyzing the effects of one of the risk factors, in this case of smoking, mainly on the amount of gingival fluid. For achieving this, measurements were carried out, in mm of the wet amount of adsorbent placed in sulcus, before and 30 minutes after smoking; held in sulcus, for 3 minutes. This procedure was repeated several times. In the end, we organized the summary table, to show the interconnection of concepts about periodontal risk. What represents the human body consists of the host which is subjected to the action of oral bacterial flora and this interaction extends in time, where the personal diet of the patient operates as mechanical element that cleans the surfaces of the tooth. It is noted that the change in wetting of the adsorbent was only 1 or 0.5 millimeters, within 3 minutes time that was held inside the sulcus. Small changes, but in total for the whole mouth, these are with great action for the oral hygiene. Once this 0.5 mm of humidity is produced in 6 different points, around the tooth, and for 32 teeth simultaneously, the cleaning action of gingival fluid is more effective. Smoking not only increases the amount of crevicular fluid, but it also promotes the destruction of the bone, whose clinical signs are visible to the naked eye.

Basal cell carcinoma (BCC) is the most frequent epithelial tumor of the skin, characterized by a local infiltrative growth in contrast to

No abstract