The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and functioning depends on multivalent interactions occurring among transcription factors, cofactors and basal transcriptional machinery. However, how chromatin players contribute to the assembly of transcriptional condensates is poorly understood. By interrogating the effect of KMT2D (also known as MLL4 ) haploinsufficiency in Kabuki Syndrome, we found that MLL4 contributes to the assembly of transcriptional condensates through liquid-liquid phase separation. MLL4 loss-of-function (LoF) impaired Polycomb-dependent chromatin compartmentalization, altering nuclear architecture. By releasing the nuclear mechanical stress through the inhibition of the mechano-sensor ATR, we re-established the mechano-signaling of mesenchymal stem cells (MSCs) and their commitment towards chondrocytes both in vitro and in vivo. This study supports the notion that in Kabuki Syndrome the haploinsufficiency of MLL4 causes an altered functional partitioning of chromatin, which determines the architecture and mechanical properties of the nucleus.

We report a fully guided-wave source of polarisation entangled photons based on a periodically poled lithium niobate waveguide mounted in a Sagnac interferometer. We demonstrate the source's quality by converting polarisation entanglement to postselection-free energy-time entanglement for which we obtain a near-optimal S-parameter of 2.75 ± 0.02, i.e. a violation of the Bell inequality by more than 35 standard deviations. The exclusive use of guided-wave components makes our source compact and stable which is a prerequisite for increasingly complex quantum applications. Additionally, our source offers a great versatility in terms of photon pair emission spectrum and generated quantum state, making it suitable for a broad range of quantum applications such as cryptography and metrology. In this sense, we show how to use our source for chromatic dispersion measurements in optical fibres which opens new avenues in the field of quantum metrology.

Beyond the use of genuine monolithic integrated optical platforms, we report here a hybrid strategy enabling on-chip generation of configurable heralded two-photon states. More specifically, we combine two different fabrication techniques, i.e., non-linear waveguides on lithium niobate for efficient photon-pair generation and femtosecond-laser-direct-written waveguides on glass for photon manipulation. Through real-time device manipulation capabilities, a variety of path-coded heralded two-photon states can be produced, ranging from product to entangled states. Those states are engineered with high levels of purity, assessed by fidelities of 99.5 ± 8% and 95.0 ± 8%, respectively, obtained via quantum interferometric measurements. Our strategy therefore stands as a milestone for further exploiting entanglement-based protocols, relying on engineered quantum states, and enabled by scalable and compatible photonic circuits.

White-light interferometry is one of today’s most precise tools for determining the properties of optical materials. Its achievable precision and accuracy are typically limited by systematic errors due to a high number of interdependent data-fitting parameters. Here, we introduce spectrally resolved quantum white-light interferometry as a novel tool for optical property measurements, notably, chromatic dispersion in optical fibres. By exploiting both spectral and photon-number correlations of energy-time entangled photon pairs, the number of fitting parameters is significantly reduced, which eliminates systematic errors and leads to an absolute determination of the material parameter. By comparing the quantum method to state-of-the-art approaches, we demonstrate the quantum advantage of 2.4 times better measurement precision, despite requiring 62 times fewer photons. The improved results are due to conceptual advantages enabled by quantum optics, which are likely to define new standards in experimental methods for characterising optical materials.

Realising a global quantum network requires combining individual strengths of different quantum systems to perform universal tasks, notably using flying and stationary qubits. However, transferring coherently quantum information between different systems is challenging as they usually feature different properties, notably in terms of operation wavelength and wavepacket. To circumvent this problem for quantum photonics systems, we demonstrate a polarisation-preserving quantum frequency conversion device in which telecom wavelength photons are converted to the near infrared, at which a variety of quantum memories operate. Our device is essentially free of noise which we demonstrate through near perfect single photon state transfer tomography and observation of high-fidelity entanglement after conversion. In addition, our guided-wave setup is robust, compact, and easily adaptable to other wavelengths. This approach therefore represents a major building block towards advantageously connecting quantum information systems based on light and matter.

Entanglement is a key resource in quantum information science and associated emerging technologies. Photonic systems offer a large range of exploitable entanglement degrees of freedom (DOF) such as frequency, time, polarization, and spatial modes. Hyperentangled photons exploit multiple DOF simultaneously to enhance the performance of quantum information protocols. Here, we report a fully guided-wave approach for generating polarization and energy-time hyperentangled photons at telecom wavelengths. Moreover, by demultiplexing the broadband emission spectrum of the source into five standard telecom channel pairs, we demonstrate compliance with fibre network standards and improve the effective bit rate capacity of the quantum channel up to one order of magnitude. In all channel pairs, we observe a violation of a generalised Bell inequality by more than 27 standard deviations, underlining the relevance of our approach.

Path-entangled multi-photon states allow optical phase-sensing beyond the shot-noise limit, provided that an efficient parity measurement can be implemented. Realising this experimentally is technologically demanding, as it requires coincident single-photon detection proportional to the number of photons involved, which represents a severe challenge for achieving a practical quantum advantage over classical methods. Here, we exploit advanced quantum state engineering based on superposing two photon-pair creation events to realise a new approach that bypasses this issue. In particular, optical phase shifts are probed with a two-photon quantum state whose information is subsequently effectively transferred to a single-photon state. Notably, without any multiphoton detection, we infer phase shifts by measuring the average intensity of the single-photon beam on a photodiode, in analogy to standard classical measurements. Importantly, our approach maintains the quantum advantage: twice as many interference fringes are observed for the same phase shift, corresponding to N = 2 path-entangled photons. Our results demonstrate that the advantages of quantum-enhanced phase-sensing can be fully exploited in standard intensity measurements, paving the way towards resource-efficient and practical quantum optical metrology.

Progress in integrated photonics enables the combination of several elementary functions on single substrates for the realization of advanced functionalized chips. We report a monolithic integrated quantum photonic realization on lithium niobate, where nonlinear optics and electro-optics properties have been harnessed simultaneously for generating heralded configurable, two-photon states. Taking advantage of a picosecond pump laser and telecom components, we demonstrate the production of various path-coded heralded two-photon states, showing 94% raw visibility for Hong-Ou-Mandel interference. The versatility and performance of such a highly integrated photonic entanglement source enable exploring more complex quantum information processing protocols finding application in communication, metrology and processing tasks.