Article:Lupo, Cosmo orcid.org/0000-0002-5227-4009, Ottaviani, Carlo orcid.org/0000-0002-0032-3999, Papanastasiou, Panagiotis et al. (1 more We present a rigorous security analysis of continuous-variable measurement-device-independent quantum key distribution (CV MDI QKD) in a finite-size scenario. The security proof is obtained in two steps: by first assessing the security against collective Gaussian attacks, and then extending to the most general class of coherent attacks via the Gaussian de Finetti reduction. Our result combines recent state-of-the-art security proofs for CV QKD with findings about min-entropy calculus and parameter estimation. In doing so, we improve the finite-size estimate of the secret key rate. Our conclusions confirm that CV MDI protocols allow for high rates on the metropolitan scale, and may achieve a nonzero secret key rate against the most general class of coherent attacks after 10 7 -10 9 quantum signal transmissions, depending on loss and noise, and on the required level of security.

We have studied the immunohistochemical expression (IE) of eight non-tissue-specific human kallikreins (hKs) (hK5, 6, 7, 10, 11, 12, 13, and 14) in different normal tissues. The IE was always cytoplasmic, showing a characteristic pattern in some tissues. Comparison of the IE of all hKs studied in the different tissues revealed no major differences, suggesting that they share a common mode of regulation. Furthermore, hKs were immunohistochemically revealed in a variety of tissues, indicating that no protein is tissue-specific (except for hK2 and hK3, which have tissue-restricted expression). In general, our results correspond well with data from RT-PCR and ELISA assays. Glandular epithelia constitute the main kallikrein IE sites, and the staining in their secretions confirms that these proteases are secreted. A variety of other tissues express the proteins as well. We have also immunohistochemically evaluated all the above hKs in several malignant tissues. Tumors arising from tissues expressing kallikreins tested positive. Corresponding to the IE in normal glandular tissues, most hKs were expressed in adenocarcinomas. The prognostic value of several hKs was studied in series of prostate, renal cell, colon and urothelial carcinomas.

Article:Papanastasiou, Panagiotis, Ottaviani, Carlo orcid.org/0000-0002-0032-3999 and Pirandola, Stefano orcid.org/0000-0001-6165-5615 (2017) We study the impact of finite-size effects on the key rate of continuous-variable (CV) measurement-deviceindependent (MDI) quantum key distribution (QKD), considering two-mode Gaussian attacks. Inspired by the parameter estimation technique developed in by Ruppert et al. [Phys. Rev. A 90, 062310 (2014)], we adapt it to study CV-MDI-QKD and, assuming realistic experimental conditions, we analyze the impact of finite-size effects on the key rate. We find that the performance of the protocol approaches the ideal one, increasing the block size, and, most importantly, that blocks between 10 6 and 10 9 data points may provide key rates ∼10 −2 bit/use over metropolitan distances.

One crucial step in any quantum key distribution (QKD) scheme is parameter estimation. In a typical QKD protocol the users have to sacrifice part of their raw data to estimate the parameters of the communication channel as, for example, the error rate. This introduces a trade-off between the secret key rate and the accuracy of parameter estimation in the finite-size regime. Here we show that continuous-variable QKD is not subject to this constraint as the whole raw keys can be used for both parameter estimation and secret key generation, without compromising the security. First, we show that this property holds for measurement-device-independent (MDI) protocols, as a consequence of the fact that in a MDI protocol the correlations between Alice and Bob are postselected by the measurement performed by an untrusted relay. This result is then extended beyond the MDI framework by exploiting the fact that MDI protocols can simulate device-dependent one-way QKD with arbitrarily high precision.

We consider discrete-alphabet encoding schemes for coherent-state quantum key distribution. The sender encodes the letters of a finite-size alphabet into coherent states whose amplitudes are symmetrically distributed on a circle centered in the origin of the phase space. We study the asymptotic performance of this phase-encoded coherent-state protocol in direct and reverse reconciliation assuming both loss and thermal noise in the communication channel. In particular, we show that using just four phase-shifted coherent states is sufficient for generating secret key rates of the order of 4 × 10 −3 bits per channel use at about 15 dB loss in the presence of realistic excess noise.

Human kallikreins 5, 6, 10 and 11 (hK5, 6, 10 and 11) are expressed by many normal tissues, and it has been suggested that they may represent candidate tumor-diagnostic or -prognostic markers. In patients with renal cell carcinoma (RCC), outcome is unpredictable despite the use of conventional prognostic factors. The aim of this study is to evaluate the immunohistochemical expression and the prognostic value of the above kallikreins in RCC. The study comprised 95 patients who underwent radical nephrectomy for RCC. The median follow-up period was 60 months (range 1–180 months). Fifty-seven RCC cases were immunostained for hK5, 70 for hK6, 70 for hK10 and 69 for hK11. The streptavidin-biotin-peroxidase method of immunostaining was performed using anti-hK5, anti-hK6, anti-hK10 and anti-hK11 monoclonal and polyclonal antibodies. The immunohistochemical expression of these kallikreins was correlated with tumor size, histological type, histological malignancy according to the Fuhrman four-grade scale, mitotic index, pathological stage and disease survival. For the statistical analysis, four grades were collapsed into two by which RCC cases were categorized as low malignant (LM) and high malignant (HM). In the normal renal parenchyma adjacent to the tumors, the renal tubular epithelium showed a cytoplasmic expression of all four kallikreins. In RCC, immunohistochemical expression was decreased: 33 of 57 cases (58%) were positive for hK5, 27 of 70 (39%) for hK6, 46 of 70 (66%) for hK10 and 32 of 69 (46%) for hK11. A statistically significant positive correlation was observed among the immunohistochemical expression of all kallikreins. HM-RCC expressed all kallikreins in a higher percentage of cases than LM-RCC, but statistically significant differences were only observed for hK6 and hK10 (55 vs. 27%, p = 0.016, and 79 vs. 56%, p = 0.044, respectively). hK6 and hK11 expression showed a positive correlation to pathological stage: hK6 with both Robson and TNM 2002 staging systems (p = 0.010 and p = 0.017, respectively), and hK11 only with the Robson staging system (p = 0.045). In both the Kaplan-Meier and the univariate Cox regression analyses, hK6 expression was negatively correlated with disease-specific survival (p = 0.05 and p = 0.038, respectively). In univariate analysis, nuclear grade, Robson stage and TNM stage also correlated with disease-specific survival. However, in the multivariate analysis, TNM stage was the only independent prognostic factor. In conclusion, although the immunohistochemical expression of hK5, hK6, hK10 and hK11 was downregulated in RCC, tumors of high grade and late stage expressed one or more of the above kallikreins in a higher percentage of cases, and hK6 may predict a poor disease outcome in RCC.

Article:Papanastasiou, Panagiotis, Weedbrook, Christian and Pirandola, Stefano orcid.org/0000-0001- 6165-5615 (2018) We investigate the performance of several continuous-variable quantum key distribution protocols in the presence of fading channels. These are lossy channels whose transmissivity changes according to a probability distribution. This is typical in communication scenarios where remote parties are connected by free-space links subject to atmospheric turbulence. In this work, we assume the worst-case scenario where an eavesdropper has full control of a fast fading process, so that she chooses the instantaneous transmissivity of a channel, while the remote parties can only detect the mean statistical process. In our study, we consider coherent-state protocols run in various configurations, including the one-way switching protocol in reverse reconciliation, the measurementdevice-independent protocol in the symmetric configuration and a three-party measurement-deviceindependent network. We show that, regardless of the advantage given to the eavesdropper (full control of fading), these protocols can still achieve high rates.

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