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We present new tradeoffs between space and query-time for exact distance oracles in directed weighted planar graphs. These tradeoffs are almost optimal in the sense that they are within polylogarithmic, sub-polynomial or arbitrarily small polynomial factors from the naïve linear space, constant query-time lower bound. These tradeoffs include: (i) an oracle with space 1 O(n 1+ ) and query-timeÕ(1) for any constant > 0, (ii) an oracle with spaceÕ(n) and query-timeÕ(n ) for any constant > 0, and (iii) an oracle with space n 1+o(1) and query-time n o(1) .

Background The deviation of the observed frequency of a word w from its expected frequency in a given sequence x is used to determine whether or not the word is avoided. This concept is particularly useful in DNA linguistic analysis. The value of the deviation of w, denoted by , effectively characterises the extent of a word by its edge contrast in the context in which it occurs. A word w of length is a -avoided word in x if , for a given threshold . Notice that such a word may be completely absent from x. Hence, computing all such words naïvely can be a very time-consuming procedure, in particular for large k.Results In this article, we propose an -time and -space algorithm to compute all -avoided words of length k in a given sequence of length n over a fixed-sized alphabet. We also present a time-optimal -time algorithm to compute all -avoided words (of any length) in a sequence of length n over an integer alphabet of size . In addition, we provide a tight asymptotic upper bound for the number of -avoided words over an integer alphabet and the expected length of the longest one. We make available an implementation of our algorithm. Experimental results, using both real and synthetic data, show the efficiency and applicability of our implementation in biological sequence analysis.ConclusionsThe systematic search for avoided words is particularly useful for biological sequence analysis. We present a linear-time and linear-space algorithm for the computation of avoided words of length k in a given sequence x. We suggest a modification to this algorithm so that it computes all avoided words of x, irrespective of their length, within the same time complexity. We also present combinatorial results with regards to avoided words and absent words.

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Given two strings S and T, each of length at most n, the longest common substring (LCS) problem is to find a longest substring common to S and T. This is a classical problem in computer science with an $$\mathcal {O}(n)$$ O ( n ) -time solution. In the fully dynamic setting, edit operations are allowed in either of the two strings, and the problem is to find an LCS after each edit. We present the first solution to the fully dynamic LCS problem requiring sublinear time in n per edit operation. In particular, we show how to find an LCS after each edit operation in $$\tilde{\mathcal {O}}(n^{2/3})$$ O ~ ( n 2 / 3 ) time, after $$\tilde{\mathcal {O}}(n)$$ O ~ ( n ) -time and space preprocessing. This line of research has been recently initiated in a somewhat restricted dynamic variant by Amir et al. [SPIRE 2017]. More specifically, the authors presented an $$\tilde{\mathcal {O}}(n)$$ O ~ ( n ) -sized data structure that returns an LCS of the two strings after a single edit operation (that is reverted afterwards) in $$\tilde{\mathcal {O}}(1)$$ O ~ ( 1 ) time. At CPM 2018, three papers (Abedin et al., Funakoshi et al., and Urabe et al.) studied analogously restricted dynamic variants of problems on strings; specifically, computing the longest palindrome and the Lyndon factorization of a string after a single edit operation. We develop dynamic sublinear-time algorithms for both of these problems as well. We also consider internal LCS queries, that is, queries in which we are to return an LCS of a pair of substrings of S and T. We show that answering such queries is hard in general and propose efficient data structures for several restricted cases.

Sequence comparison is a prerequisite to virtually all comparative genomic analyses. It is often realised by sequence alignment techniques, which are computationally expensive. This has led to increased research into alignment-free techniques, which are based on measures referring to the composition of sequences in terms of their constituent patterns. These measures, such as q-gram distance, are usually computed in time linear with respect to the length of the sequences. In this paper, we focus on the complementary idea: how two sequences can be efficiently compared based on information that does not occur in the sequences. A word is an absent word of some sequence if it does not occur in the sequence. An absent word is minimal if all its proper factors occur in the sequence. Here we present the first linear-time and linear-space algorithm to compare two sequences by considering all their minimal absent words. In the process, we present results of combinatorial interest, and also extend the proposed techniques to compare circular sequences. We also present an algorithm that, given a word x of length n, computes the largest integer for which all factors of x of that length occur in some minimal absent word of x in time and space O(n). Finally, we show that the known asymptotic upper bound on the number of minimal absent words of a word is tight.

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