The aim of this study was to assess the quality of life (QoL) of women with breast cancer during chemotherapy and to identify the incidence of nausea and vomiting during the treatment Data were assessed with the application of the instrument of the European Organization for Research and Treatment of Cancer, EORTC-QLQ-C30 Portuguese version and breast cancer module BR-23, which was applied before, in the middle and in the end of the treatment. The participants were 79 women, of which 93% had nausea and 87% had vomited at least once during the treatment. QoL showed a slight decrease during treatment. Cronbach's alpha for each application of the questionnaires was 0.890492, 0.936392 and 0.937639. The availability of treatment information and guidelines on the management of nausea and vomiting is crucial for the proper management of the toxicities of chemotherapy.
Objetivo: identificar a ocorrência de alterações no sono antes, durante e após o tratamento quimioterápico e correlacionar as alterações do sono com episódios de fadiga em mulheres com câncer de mama. Método: participaram do estudo 26 mulheres seguidas no Ambulatório de Mastologia de um hospital universitário que responderam o Pittsburgh Sleep Quality Index e a Functional Assessment of Cancer Therapy Fatigue para avaliar o sono e a fadiga respectivamente, em três momentos. Resultados: as participantes apresentaram distúrbios do sono, ao longo do tratamento, caracterizados por calor noturno e dificuldade em iniciar o sono e que influenciaram na piora da qualidade do mesmo. Houve correlação entre qualidade do sono e fadiga, sendo que a má qualidade do sono aumentou os episódios de fadiga. Conclusão: a identificação da ocorrência destes eventos durante a quimioterapia favorece que a equipe profissional realize orientações para manejo adequado dos eventos adversos.
The present research is an analytical and prospective study of quantitative approach that aimed to assess the relationship between sleep disturbances and fatigue before, during and after chemotherapy in women with breast cancer. The specific objectives were to identify possible changes in sleep and fatigue events among these women, as well as sleep disturbances correlate with episodes of fatigue. To assess the quality of sleep the instrument applied was the Pittsburgh Sleep Quality Index-PSQI and for evaluating the fatigue scale was used Functional Assessment of Cancer Therapy-FACIT-F fatigue version 4. Three successive applications of instruments were done before starting chemotherapy, in the middle, and after the last cycle. The statistical analysis was performed using the Statistical Software Package for Social Sciences (SPSS) version 16, using the Fisher's exact test for relate the variables of sleep and fatigue with the sociodemographic factors, and Spearman test to correlate sleep with fatigue. The sample consisted of 26 women diagnosed with breast cancer, with a mean age of 48 years, of which 65.4% of them had a partner, 57.7% had 3-10 years of education and 65.3% reported at least one comorbidity. The protocols used were chemotherapy fluorouracil, epirubicin and cyclophosphamide (FEC), epirubicin, cyclophosphamide and docetaxel (EC-T), epirubicin, cyclophosphamide, Docetaxel and Trastuzumab (EC-HT) and docetaxel, carboplatin and Trastuzumab (TC-H). Marital status was important for the sleep quality of participants, as well as physical activity to fatigue. Most women reported sleeping seven to nine hours per night. The sleep quality of participants was good before starting chemotherapy and in the middle of treatment, after the last chemotherapy most women had poor sleep. Fatigue levels were low, most women had little sense of fatigue. Sleep and fatigue symptoms were significantly correlated in the middle and the end of treatment. Therefore, there was a significant relationship between sleep quality and fatigue that was important for the occurrence of these two symptoms. It is believed that identify the occurrence of adverse events to chemotherapy and thereafter the nursing staff conduct guidelines for the management of these symptoms, are needed before the discomfort generated and interfere in the well-being of women
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