The current study was conducted for 75 days to evaluate the impact of Potassium diformate (KDF), Sodium formate (SF) and organic acid blend (KDF + SF) on the growth, immunity and disease resistance in Penaeus vannamei against Vibrio harveyi. Pacific white shrimps (2.11 ± 0.01g) were fed with organic acids and organic acid blend in two different inclusion levels, such as 1 & 2%. After 60 days of feeding trial, the higher body weight gain and survival rate was observed in shrimps fed KDF 2% diet compared to the control groups. Challenge study conducted for 15 days with V. harveyi (108) has shown significantly lower cumulative mortality rate in shrimps fed KDF 2%, KDF 1% and SF 2% treatment groups compared to the control groups. At the end of challenge study, total cultivable bacteria and presumptive vibrio spp. count in shrimp fed KDF2 and all treatments were significantly lower than control diet. The histopathology results were observed with less hepatopancreatic damage in shrimps fed with KDF at 2% level compared to the control. The immune parameters, Total haemocyte count (THC), Prophenoloxidase activity (proPO), Respiratory burst activity (RBA), Superoxide dismutase (SOD), and Catalase activity (CAT) were found to be significantly higher than the control.
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