Lichen planus (LP) is a common papulosquamous skin disease with a prevalence 1-2% globally and 0.1 - 1.5% in Indian studies with many morphological presentations. LP is strongly associated with chronic HCV infection (3.1- 18.3% in different studies), while the association with other viral infections (Hepatitis B and HIV) is not that strong. There are only a few studies in Indian patients and the association reported is not uniform. Further studies will help to consolidate the association.1) To study the epidemiological and clinico- histopathological pattern in LP. 2) To determine the serology and assess the possible association with HCV, HBsAg and HIV.140 patients of LP after histopathological confirmation were tested for detection of HCV antibodies, Hbs antigen and HIV antibodies by HCV-TRIDOT, HEPACARD and HIV –TRIDOT respectively. Statistical analysis was performed by SPSS software 20.0.Most common age group involved was 21-30 years. 75.6% of the patients presented with in 6 months of onset. Extremities and trunk were commonly involved. The most common clinical variants are classical LP(35%) and hypertrophic LP(31%). Mucosal involvement alone was observed in 9.3% patients . HBs Ag was positive in 4 cases , Anti HCV antibodies were positive in 3 cases and HIV was reactive in 3 cases.There is no significant relationship between LP and Hepatitis B, C and HIV virus. It may be suggested that viral serology (HBV, HCV, HIV) may not be necessary in routine screening for LP.

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