There is high prevalence of vitamin D deficiency among pregnant women in India. Women with preeclampsia had significantly lower vitamin D level as compared to normal women. Severity of the disease was not related to vitamin D level.

Background:There is an alarming rise in caesarean section leading to increased adverse outcomes for both the mother and fetus when compared with vaginal delivery. Within this increasing caesarean section rate, there is a concerning increase in the rate of second stage caesarean section. This study highlight the feto-maternal outcome of caesarean section in second stage of labour.Methods: This was a retrospective cohort review of all women with a singleton, cephalic fetus at term delivered by caesarean section in the second stage of labor between April 1, 2013 and March 30, 2017 at Patan Academy of Health Sciences. The main outcome measures were second stage caesarean section, indications and its maternal and fetal morbidity.Results: During the study period, there were 40,860 deliveries. A total of 18,011 (44%) babies were born by caesarean section, 10484 emergency and 7527 elective. Out of the emergency caesarean section, 200 (1.9 %) were performed in second stage of labor. In this study, the most common indication was cephalopelvic disproportion. (92.4%) were delivered without a trial of instrumental delivery. In terms of maternal complications, atonic post partum haemorrhage uterine incision extension 18 (12.5%), postoperative fever 27(18.8%), wound infection 7 (4.8%) were observed. In perinatal complications, meconium stained amniotic fluid 49(34.2%), neonatal hyperbilirubinemia 14(9.7%) and increased nursery admission 2(15.3%) and 2(1.3%) perinatal mortality were seen. Conclusions:Cesarean sections done in second stage of labor are associated with several intra-operative maternal complications and neonatal morbidity.

Introductions:Obstetricians have long debated the role of caesarean section as a potentially safer mode of delivery for the fetus with breech presentation. However, the experience of the health care provider remains a critical element in the decision to pursue a vaginal breech delivery, and it may still be a viable option. The aim of this study is to determine the incidence of breech delivery at Patan Hospital and compare maternal and neonatal outcomes subjected to either vaginal or caesarean section. Methods:This was a five-year retrospective study of breech deliveries covering the year 2010 to 2014. Patient's charts were retrieved from the medical record section and reviewed.Results: There were 896 breech deliveries out of a total 44,842 deliveries giving an incidence of 1.99%. One hundred thirteen (12.61%) of breech deliveries were through vaginal route while 431 (48.10%) and 352 (39.28%) were through emergency and elective caesarean sections respectively. There were 154 (17.18%) preterm breech deliveries including 27 (17.5%) preterm intrauterine death. Among term pregnancy, there were 3 neonatal deaths not associated with mode of delivery. None of the term infant had neurological morbidity comprising neonatal seizures, brachial plexus injury, chephalohematoma. Maternal blood loss was significantly higher in caesarean section group. Conclusions:In well-selected cases, the neonatal outcome following assisted vaginal breech delivery and caesarean section may not be different.

Introductions: Relaparotomy after caesarean section is rare and literature are scanty. The decision requires a good clinical judgment to save mother’s life. Our objective was to analyse the outcome of relaparotomy after caesarean section at Patan Hospital.Methods: This was a cross sectional study done at the department of obstetrics and gynaecology, Patan Hospital, Lalitpur, Nepal. Charts of the caesarean section from January 2010 to December 2014 were reviewed to analyze the cases of relaparotomy for incidence, indication, management and outcome. Descriptive analysis was done using SPSS.Results: During 5 years, there were 17,538 caesarean deliveries, 39.15% of total 44,788 deliveries. Relaparotomy was done in 15 cases, 0.085% of 17,538 caesarean. Mean age was 26.6±4.7 years, 14 (93.3%) were between 25-35 years, 12 (80%) were primigravida. Indications for relaparotomy were pyoperitoneum (40%), hemoperitoneum (33.3%) and rectus sheath hematoma (26.7%). Out of 15 relaparotomies, 14 were conservative surgery and one required hysterectomy. There was no maternal mortality.Conclusions: Relaparotomy rate in our study was eight in 10,000. Those requiring relaparotomy had fetal distress as indication for first caesarean.Journal of Patan Academy of Health Sciences. 28 2016 Dec;3(2):28-31

BackgroundChronic Myeloid Leukemia (CML) is caused by the abnormal fusion protein BCR-ABL1, a constitutively active tyrosine kinase and product of the Philadelphia chromosome. Gleevec (Imatinib mesylate) is a selective inhibitor of this kinase. Treatment with this agent is known to result in hematologic, cytogenetic, and molecular responses. Patan hospital (Patan, Nepal) is one of the Gleevec International Patient Assistance Program (GIPAP) centers for patients with CML.MethodsA total of 106 Philadelphia positive CML patients were enrolled in our center between Feb 2003 and Jun 2008, and 103 of them were eligible for cytogenetic and/or hematologic response analyses.ResultsOut of 103 patients, 27% patients underwent cytogenetic analysis. Imatinib induced major cytogenetic responses in 89% and complete hematologic responses in almost 100% of the patients with confirmed CML. After a mean follow up of 27 months, an estimated 90% of the patients on imatinib remained in hematologic remission and more than 90% of the patients are still alive. About 30% of patients developed some form of manageable myelosuppression. A few patients developed non-hematologic toxic side effects such as edema and hepatotoxicity.ConclusionsOur study demonstrates that imatinib is safe to use in a developing country. Furthermore, we demonstrate that imatinib is very effective and induced long lasting responses in a high proportion of patients with Ph chromosome/BCR-ABL1 positive CML. Imatinib is well tolerated by our patients. The lack of cytogenetic analysis in the majority of our patients hindered our ability to detect inadequate responses to imatinib and adjust therapy appropriately.

Introductions: Stillbirth (SB) is one of the most common adverse outcomes of pregnancy. The aim of this study was to determine the SB rate and to identify the likely causes contributing to SB. Methods: This cross-sectional study was conducted at Patan Hospital from 15th June 2014 to 14th June 2017 for all the cases of SBs, at or after 22 weeks, birth weight of 500 gm or more. The perinatal outcome, demographic profile, fetal characteristics, causes and contributing factors were analyzed. Results: There were 262 SB out of total 23069 deliveries, (11.24 per 1000) and 119 (46.12%) had antenatal check-up (ANC) at Patan Hospital. The 214 (82.95%) SB were among 20-34 years mothers, 133 (51.55%) being multigravida. Antepartum SB were 234 (89.31%), macerated 213 (81.30%), birth weight <1000gm 86 (32.82%) and male 156 (59.54%). The intrauterine growth restriction (IUGR) was present in 60 (22.90%), unexplained casue in 43 (16.41%), prematurity 28 (10.69%), congenital anomalies 26 (9.92%), pre-eclampsia 19 (7.25%), gestational diabetes, and abruptio placenta each 13 (4.96%). Delay in seeking care in 202 (78.30%) was a potential contributing factor. Conclusions: The SB was 11.24/1000 births. The causes in descending order were IUGR, unexplained, prematurity, congenital anomalies, pre-eclampsia, gestational diabetes and abruptio placenta. Delay in seeking care was found as a potential contributing factor.

Introduction: Maternity services were disrupted during nationwide COVID-19 lock down period. This study aimed to evaluate the impact of nationwide COVID-19 lock down on antenatal visits and obstetric outcomes in a tertiary hospital of Nepal. Method: A study was conducted at Patan hospital, Nepal with regard to antenatal visits and obstetric outcomes during COVID-19 lockdown period (24th March to 14th June 2020) and was compared to non COVID-19 period (24th March to 14th June 2019). A Chi-square test was used to determine the association between the outcome variables. The data was taken as statistically significant when the p-value was <0.05. Result: A total of 4,157pregnant women visited antenatal clinic (ANC) during nationwide COVID-19 lock down period while 7,029 patients visited during same period a y back (non COVID-19 period) which is a 40.86 percentage decline. There was significant reduction in deliveries during COVID-19 lock down period (1604 during non COVID-19 and 1140 deliveries during COVID-19 lockdown period respectively) but mode of delivery was similar. Maternal complications like postpartum hemorrhage (PPH), intensive care stay (ICU), sepsis and cesarean hysterectomy were similar during both the period. There was a significant reduction in preterm deliveries during COVID-19 lock down period (13 during non COVID-19and 8.7 percentage during COVID-19 period respectively). However, early neonatal sepsis (EONS) was significantly higher during COVID-19 lock down period. Conclusion: While, there was a significant reduction in preterm births and increase in early neonatal sepsis during COVID-19 lockdown period, there was no difference in maternal outcome.

Introduction: Hypertensive disorder of pregnancy is among the leading causes of maternal and perinatal mortality in developing countries. There are only few studies regarding this topic so this study helps us to improve our management protocol thereby reducing maternal and foetal morbidity and mortality. The aim of this study was to find out the prevalence of pregnancy induced hypertensive disorder among patient admitted to the Department of Obstertric and Gynecology in a tertiary care centre. Methods: A descriptive cross sectional study was conducted in the Department of Obstetrics and Gynaecology of tertiary care centre from 30 July 2020 to 30 July 2021 after obtaining ethical approval from the Institutional Review Committee (Reference number: 2007211399). Convenience sampling method was used among patients who met the eligibility criteria. Point estimate and 95% Confidence Interval were calculated. Results: Among 4,303 deliveries, hypertensive disorder in pregnancy was seen in 110 (2.55%) (2.08-3.03, 95% Confidence Interval) Among 110 (2.55%) patients, preeclampsia was seen in the majority of the patients 69 (62.72%). Conclusions: The prevalence of hypertensive disorder among pregnancies was similar to the other studies done in similar settings. Hypertensive disorder poses a major issue in pregnant women so should be taken into a serious matter as it causes major problems in maternal and foetal outcomes.