Introduction: Osteoarthritis is one of the leading causes of disability having high prevalence in elderly
population. There is a large debate regarding usage of biologicals in treatment of OA knee. The purpose
of this study is to evaluate the efcacy and safety of intra articular PRP injection in treatment of OA knee. Materials and
methods: 50 patients were enrolled in this prospective non-randomized study.10 patients were lost to follow up.40 patients and
55 knees were studied .All of them received 2 doses of 5ml intraarticular PRP injection 3 weeks apart. The WOMAC scores and
VAS scores at baseline, 1month, 3months and 6 months follow up are compared. Results: Out of 40 patients 25 had unilateral 15
had bilateral symptomatic osteoarthritis knee. A total of 55 knees were studied. 9 patients were males and 31 were females with
mean age of 55.65yrs and mean BMI of 29.2. According to KL grading 40 knees were grade 3 and 15 were grade 4.There is
statistically signicant (p<0.001) decrease in VAS scores and improvement in WOMAC functional scores after 2 doses of PRP
injections. No signicant adverse effects were observed. Conclusion: Intraarticular PRP injection is safe, well tolerated and
effective in treatment of primary osteoarthritis. There is decrease in pain and improvement in functional outcome after 2 doses
of PRP. More well designed RCT'S with large sample and long term follow up are required to establish long term effectiveness of
PRP injections.
The SiO2 glasses embedded with Cr3+ ions are notable for solid state optical resource, which are useful in various opto-electronic and semiconducting applications. However, the available thermoluminescent resource, which include different electronic and semiconducting materials, need some refinement in their structure, luminescence, and electronic properties towards development of advanced glass resource. In this vision, CrxCa(10-x)Al30Si60 glassy materials have planned for synthesis and testing. The GT, and GC phase transition points, and thermal stability (~1.2639) of test samples are identified. Structural vibrations are identified with the help of FT-IR spectra. The order of electrical conductivity (~1.657x10-4 ohm-1 cm-1), and A.E. (~0.3669 eV) of test samples reveal their electrical strength. The symmetry (~ 0.576%) factor, frequency (1.1172 X 1020 S -1) factor, and A.E. (0.682 eV) of the test samples are recorded under 30 kGy irradiation. Overall, the results, which include structure, electrical and luminescence of the test samples suggest the materials might be useful electrically conductive and thermal stimulated light resource.
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