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Biodegradable polymeric microneedles containing atorvastatin calcium were developed in order to improve the percutaneous absorption of the drug, useful for the treatment of hypercholesterolemia. The microneedles were made with poly (methyl vinyl ether-alt-maleic acid) as biodegradable polymer using the technique of casting in solution in a mold. After solidification these microneedles were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), bioadhesion, post wetting-bioadhesion, breaking strength, drug release test and in vitro percutaneous absorption studies. In general, the performances were satisfactory for optimal formulation in terms of DSC with no interactions between drug and excipients, SEM shows microneedles with a conical shape, bioadhesion of 1570 g.f, post wetting-bioadhesion of 1503.4 g.f, breaking strength of 1566.7g.f that is sufficient to disrupt stratum corneum, drug release (more than 90% in 40 min) and a flux of 33.4 µg/cm2*h with a tLag of 15.14 h for the in vitro percutaneous absorption studies.
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