The five muscarinic acetylcholine receptors (M(1)-M(5)) are differentially expressed in the brain. M(2) and M(4) are coupled to inhibition of stimulated adenylyl cyclase, while M(1), M(3) and M(5) are mainly coupled to the phosphoinositide pathway. We studied the muscarinic receptor regulation of adenylyl cyclase activity in the rat hippocampus, compared to the striatum and amygdala. Basal and forskolin-stimulated adenylyl cyclase activity was higher in the striatum but the muscarinic inhibition was much lower. Highly selective muscarinic toxins MT1 and MT2-affinity order M(1) > or = M(4) >> others-and MT3-highly selective M(4) antagonist-did not show significant effects on basal or forskolin-stimulated cyclic AMP production but, like scopolamine, counteracted oxotremorine inhibition. Since MTs have negligible affinity for M(2), M(4) would be the main subtype responsible for muscarinic inhibition of forskolin-stimulated enzyme. Dopamine stimulated a small fraction of the enzyme (3.1% in striatum, 1.3% in the hippocampus). Since MT3 fully blocked muscarinic inhibition of dopamine-stimulated enzyme, M(4) receptor would be responsible for this regulation.
En este trabajo el autor analiza el derrotero del suplemento cultural del diario La Prensa (1951-1955), centrándose en aquellos artículos escritos por los representantes de la llamada «izquierda nacional», en cuanto a su vinculación política con el peronismo. En la publicación colaboró un amplio elenco de periodistas, escritores e intelectuales, desde viejos «martinfierristas» y del núcleo literario «Boedo», hasta nacionalistas de cuño revisionista. Sobre esta premisa, el autor examina la influencia de dichos textos durante el primer peronismo y como gravitaron en el mundo cultural de su época.
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