A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg(-1) was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.
The Polycyclic Aromatic Hydrocarbons (PAHs) are the most widespread organic environmental pollutants. PAHs are found in motor vehicle exhaust. Some PAHs are found in medicines, dyes, plastics, pesticide, naphthalene balls and wood preservatives. The compounds under the presences of Sun light generally activated and inhibited the cell growth. Hence the present investigation was focused on the maintenances and culturing of NIH-3T3 and L-929 cell lines derived from mouse fibroblast as well as the phototoxicity assessment of PAHs compounds (Benzo(a) pyrene, Pyrene) in these cell lines. Monolayer culture of cell lines was grown in DMEM culture medium. Live cells were attached in cryovial check surface and dead cell was mixed in the medium and rise up on the upper layer on the medium. The result showed that the singlet oxygen (1 O 2) generation by benzo(a)pyrene and pyrene showed the phototoxicity at various concentration from 5-50 ppm under the exposure of UV-A (5.76 J/cm2), UV-B (2.16 J/cm2) and sunlight 60 min. Rose Bengal (50 ppm) was used as the positive control. Pyrene generated the more amount of singlet oxygen as compared to Benzo(a)pyrene while Benzo(a)pyrene generated more superoxide as compared to Pyrene.
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