No abstract

We studied histologically antral biopsies from 89 consecutive patients with chronic renal failure for Helicobacter pylori (previously Campylobacter pylori). A dose-response gastric secretion test was also performed. The frequency of Helicobacter-positive subjects was low (15/89, 17%), corresponding to figures reported in the literature for young symptomless volunteers. Helicobacter-positive patients had significantly more frequently upper gastrointestinal symptoms than Helicobacter-negative individuals (P less than 0.05). Antral gastritis was more common in the Helicobacter-positive than in the Helicobacter-negative renal patients (P less than 0.01), but the incidence of body gastritis did not differ between them. The Helicobacter-positive patients had lower serum urea levels (P less than 0.01) and higher acid outputs (P less than 0.001) than Helicobacter-negative subjects. All patients had raised fasting serum gastrin levels, which possibly obscured the difference between Helicobacter-positive (283 pg/ml) and -negative (331 pg/ml) patients. We conclude that in chronic renal failure gastric colonization of Helicobacter pylori is not more frequent than usual. It correlates positively with antral gastritis, gastric acid output and upper gastrointestinal symptoms, but negatively with serum urea levels.

A prostatic tumour removed suprapubically in a 57-year old man was found to be a malignant fibrous histiocytoma. Postoperative radiation therapy was given and 3 1/2 years later chemotherapy, epirubicin was initiated due to a local recurrence and lung metastases. Now 6 years later the health condition is good, lung metastases have not proceeded. Adjuvant radiation and chemotherapy after surgery may have a favourable effect on the outcome of MFH of the prostate.

Eosinophilic pustular folliculitis is a rase dermatosis and the treatment is difficult because the underlying pathogenic mechanism is unknown. The authors report a case of eosinophilic pustular folliculitis (Ofuji's disease) in a 50-year-old man who died 9 years after onset of the disease.

By usinga radioimmunological method (1) Jakobsson, Lindberg et a1 have found an increased absorption or the macri~molecule human alactalbumin (LA) in infants wiLh qostrolntesti~~d disorders, such as cow's mllk allergy and infantile colic. This study was performed to answcr thc questior~ if there 1s an increased macromolecular absorption during the acute (immediately after rehydration) and convalescent (after 4-9 weeks) phase of gastroenteritis. Rota-virus was found In 17 of the 20 children studied. Serum samples were analyzed for LA at 30 and 60 minutes after an lntake of human milk. 20 children (aged 1-29 munths) were studied in the acute phase. 19 of them had Lhe same low or nnn~r~easurable amount of LA In serum (mean values 3 3~9 LA/I scrun~/human milk/kg body welght) as age matched controls (n-90). 11 cli~ldren were studied aqair~ in the convalescent phase. 8 of these 11 chlldren had an incrcased concentration of S-LA (mean value 12.5.0) in comparison witli the acute phase. 6 had significantly higher concentration than the controls. Conclusion: Children with gastroenteritis caused by rotavirus does not have an increased absorption of macror~~olecules (human LA) In the acute phase but an increased absorption was observed 4-9 weeks after the acute phase.