Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differences (SAPID), and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (P = .007), PID at 8 hours (P = .02), and SAPID 0–8 hours (P < .0001). It also showed faster onset of action (42 minutes) and longer duration of action (6.5 hours). The adverse events were comparable in both groups. Conclusion. Single dose of dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.

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Background: Commonest complaints for which patients seek hospital care are upper gastrointestinal (UGI) symptoms.  Prevalence of these symptoms range from 8-54%. Most common cause is Helicobacter pylori. The objective of this study was to investigate incidence of Helicobacter pylori in patients with UGI symptoms.Methods: Hospital-based study was carried out among 200 cases with esophageal disorders, gastric disorders, duodenal disorders, gastro duodenitis. Predesigned and pretested questionnaire was used to record information. Gastric and duodenal biopsy was taken. Rapid antigen test kit was used to identify for Helicobacter pylori. Results: Incidence of Helicobacter pylori was 80%. Most common disorders associated with UGI symptoms were gastritis (29%), gastritis with duodenal ulcer (21%) and esophagitis (21%). They were more common in males except esophageal varices. Gastritis and esophagitis were significantly more in 21-40 years (46.55%) (p<0.05). Most common age of UGI symptoms was 21-40 years (34.5%). H. pylori infection was more among males (62.50%). Most common indication for endoscopy was dyspepsia in 48 (24%).Conclusions: Incidence of H. pylori was 80%. Upper GI diseases are more common in men (65.5%) compared to females (34.5%) with the most affected age group between 21-60 years (68%). H. pylori was the commonest cause of chronic gastroduodenitis in this study.