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Introduction Myoepithelioma primarily affects the parotid gland and usually presents as a slow-growing painless lump. The aim of this paper is to report a case of myoepithelioma in the mouth floor. Case outline A young man noticed a painless increased volume in the left side of the mouth floor region, which after one year of evolution presented as a sessile tumor with normal colored mucosa and the absence of secretion output. Computed tomography with contrast showed an image with slightly heterogeneous density, with well-defined limits. Incisional biopsy was performed under local anesthesia, and pathology examination of the sample revealed a myoepithelial neoplasm. Total excision of the lesion was performed under general anesthesia, and histopathological examination confirmed the diagnosis of the salivary gland myoepithelioma. The patient did not present signs of relapse after a year of follow up. Conclusion Despite the fact that myoepithelioma originating in the salivary gland are considered rare, especially in the mouth floor, this tumor should be considered in the differential diagnosis of similar lesions. Proper treatment appears to be complete surgical excision and post-operative follow-ups shows should be carried out as long as possible, despite the fact that relapses are extremely rare.