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Lectin-dependent cell-mediated cytotoxicity of peripheral blood mononuclear cells from patients with uterine cervix carcinoma was evaluated using human adherent 3H-TdR-prelabeled HEp-2 epipharynx carcinoma cells as targets at a 50:1 effector-target cell ratio with 25 micrograms concanavalin A/ml in a 24-h assay. Peripheral blood mononuclear cells from 13 patients with cervical carcinoma in stage IV failed to exert cytotoxicity against HEp-2 targets. In contrast, an increased survival (decreased detachment from the monolayer) of HEp-2 cells was observed in the presence of peripheral blood mononuclear cells from patients, this being significantly enhanced by addition of concanavalin A during the lectin-dependent cell-mediated cytotoxicity assay.

The technological advancement of autonomous vehicles has accelerated in recent days: the number of street tests conducted in the daily traffic of cities is increasing dynamically, and so are the numbers of cities involved, participating developers, and tested vehicles. It can also be observed that not only self-driving cars are being tested on the street now; self-driving buses and trucks are also appearing on public roads, and on the pavements a lesser-known type of vehicle can be found, the so-called autonomous city delivery robots. There are several international studies on the social acceptance of self-driving vehicles, but the vast majority of them focus on self-driving cars. We have little information about how the urban population relates to autonomous delivery robots, which travel on the pavement and can come into much more direct contact with residents than their counterparts that travel on the road or in the air. Our study, by means of netnography and questionnaire research, as well as motion picture sentiment research, analyses Hungarian society's attitude towards self-driving transport vehicles.

Objective: The aim of the study was to examine the temporal relations between the parameters of the maternal hemodynamics and homeostasis in different phases of pregnancy and the postpartum period. Methods: Eleven healthy pregnant women were involved in the study. The value of the peripheric vasodilatation was measured by the ratio 1/A of the maternal sphygmogram (I: incisure point, A: amplitude of the carotid pressure curve). The change of the cardiac output was determined by the ejection angle composed from maternal carotid sphygmogram and its first electrical derivate (dP/dT). The glomerular filtration rate (GFR) was measured with the in vitro radiofluorescent method. Results:The primary peripheral vasodilatation and GFR increase occur early in the first trimester of a normal pregnancy, start to decrease at the end of the third trimester, and return to the normal value in the postpartum period. The increase of GFR precedes the increase of cardiac output. The cardiac output increases progressively from the first trimester and starts to decrease in the third trimester of a normal pregnancy. The extracellular volume increases at the beginning of first trimester progressively until the end of pregnancy and returns to the normal value in the postpartum period. Discussion:The increase of GFR and the cardiac output during pregnancy are contributed to volumeestablishment and to the cessation of the special "underfilled" condition of the maternal circulation in the normal pregnancy. We suppose that the maximal increase of GFR precedes the maximal increase of the cardiac output because the GFR increase is caused by maximal renal vasodilatation. The increase of cardiac output is caused in the first trimester by the shunt effect of the enhanced renal blood flow of maternal kidneys, and in the second and third trimester by the shunt effect of the feto-placental unit and the shunt effect of the maternal kidneys.