Novel binuclear Co(II) complexeswithN-functionalized cyclam N,N?,N",N???-tetrakis( 2-pyridylmethyl)tetraazacyclotetradecane (tpmc) and one of the aromatic monoor dicarboxylato ligands (benzoate, phthalate or isophthalate ions) were prepared. They were analyzed and studied by elemental analyses (C, H, N), electrical conductivities, VIS and IR spectroscopy andmagnetic as well as cyclic voltammetric measurements. In [Co2(C6H5COO)2tpmc]ClO4)2.3H2O, the benzoate ligands are most probably coordinated as chelates in the trans-position to each Co(II) and the macrocycle adopts a chair conformation. In the complexes [Co2(Y)tpmc]ClO4)2.zH2O, (Y = phthalate or i-phthalate dianizon, z = 2; 4) it is proposed that the isomeric dicarboxylates are bonded combined as bridges and chelates. The composition and the assumed geometries of the complexes are compared with the, earlier reported, corresponding Cu(II) complexes. Cyclic voltammetry measurements showed that the compounds are electrochemically stable.
Eight mixed-ligand cobalt(III) complexes with the macrocyclic amine 1,4,8,11-tetraazacyclotetradecane (cyclam) and a heterocyclic dithiocarbamate (Rdtc-)i.e., morpholine-(Morphdtc), thiomorpholine- (Timdtc), piperazine-(Pzdtc), N-methylpiperazine-(Mepzdtc), piperidine- (Pipdtc), 2-, 3- or 4-methylpiperidine-(2-, 3- and 4-Mepipdtc) carbodithionato-S,S ions, of the general formula [Co(cyclam)Rdtc](ClO4)2, were investigated in deoxygenated 0.1 MHClO4 solutions. Cyclic voltammetry data at a glassy carbon (GC) electrode demonstrate a redox reaction of cobalt(III) from the complexes at potentials strongly influenced by the presence of different heterocyclic Rdtc- ligands. In this respect, the complexes were separated into two groups: the first, with a heteroatom O, S or N in the heterocyclic ring, and the second, with a methyl group on the piperidine ring of the Rdtc- ligand. Anodic polarization of an Fe electrode in the presence of the complexes shows their influence not only on the dissolution of iron but also on the hydrogen evolution reactions and on this basis complexes the complexes could be divided into the same two groups. It was found that the weaker the inhibiting effect of the free heterocyclic amines is, the significantly higher is the efficiency of the corresponding complexes.
Five new dioxomolybdenum(VI) complexes of the general formula [MoO 2 (Rdtc) 2 ], 1-5, where Rdtc -refer to piperidine (Pipdtc), 4-morpholine (Morphdtc), 4-thiomorpholine (Timdtc), piperazine (Pzdtc) or N-methylpiperazine (N-Mepzdtc) dithiocarbamates, respectively, have been prepared. The complexes were characterized by elemental analysis, conductometric measurements, electronic, IR and NMR spectroscopy. The complexes 1-5 contain a cis-MoO 2 group and have an octahedral geometry. Two dithiocarbamato ions join as bidentates with both the sulfur atoms to the molybdenum atom. The presence of different heteroatoms in the piperidinо moiety influences the ν(C N) and ν(C S) vibrations, which wavelengths decrease in the order: Pipdtc > N--Mepzdtc > Morphdtc > Pzdtc > Timdtc ligands. Based on their spectral data, the molecular structures of complexes 1-5 were optimized at the semi-empirical molecular-orbital level, and the geometries, as obtained from calculations, are described. The antimicrobial activities of the complexes were tested against nine different laboratory control strains of bacteria and two strains of the yeast Candida albicans. All the tested strains were sensitive. Complexes bearing heteroatom in position 4 of piperidine moiety were significantly more potent against the tested bacteria compared to the corresponding ligands.
The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifl uoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH 1 and LDH 2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH 2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro-and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.
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