Aim: Siddha diagnostic method neerkuri includes the visual observation of urine directly or by adding one drop of gingelly oil on the urine surface. The study is an effort to understand the non-invasive affordable Siddha method of identifying pathological disorders, which may be used for both diagnostic and prognostic purposes in COVID cases. The present aim is to observe the changes in the urine before and after the Siddha fixed treatment regimen and validate the effectiveness of neerkuri-neikuri urine test mentioned in Siddha texts. Presentation of Case: This study was conducted among ten patients with SARS-CoV2 infection admitted in Kokila Siddha Hospital and Research Centre, COVID-ward. They underwent modern tests as well as Siddha diagnostic test neerkuri-neikuri and the results interpreted. For adequate assessment, the entire procedure was captured in the form of video clips. Discussion: The foundation of neerkuri-neikuri is one of the Envagaithervu (Eight-fold assessment) of Siddha diagnosis based on three humor theory, fundamental physiology and it alter with specific infection. The neerkuri-neikuri tests are rational criteria that are comprehensive to understand one's health and illness status based on Siddha physiopathology. Conclusion: After the administration of the Siddha intervention, the neerkuri-neikuri test results also showed good improvement along the clinical symptoms and modern laboratory parameters of patient tests. The prognostic clinical findings and modern test results were also simultaneously reflected in the neerkuri-neikuri tests. After the completion of Siddha treatment, the neikuri patterns also reached single kabha humor in muthu (pearl), vatha humor in aravu(snake) and sangu (conch-shell) patterns from three humor state, which indicated a good prognosis.