A family with Pfeiffer's syndrome is presented in which members of two generations showed only partial but relevant syndactyly before a child was born, in the third generation, with the full acrocephalosynd:ctyfy syndrome. The acrocephalosyndactyly syndromes are a group of hereditary disorders which manifest with anomalies of the cranium, hands, and feet. As with other dominantly inherited syndromes the clinical picture varies considerably and this has led to conflicting views about the classification of the acrocephalies. Most authors recognise Apert's, Pfeiffer's and Chotzen's syndromes and there is uncertainty about
Summary. The dermatoglyphic findings from 54 females with XXX sex chromosomes are reported. Sole prints were available for study in 33 cases.Compared with female controls, an excess of radial loops and arches and a reduced mean for total finger ridge-count were the main peculiarities on the fingers.On the palms, the absence of pattern in areas I and II, and wider ridges in the a-b interval were characteristics observed. Previous findings by other authors with respect to: (1) zygodactylous tendency in the palms, (2) tendency for the ridge width to increase with the number of sex chromosomes, and (3) greater effect of an extra X chromosome in pattern size reduction but lesser influence on ridge width than an additional Y chromosome, were confirmed.On the soles, pattern intensity was above the control average. There was a significant deficit of proximal loops in area III but an excess of proximal V together with triradius h. Triradius pi and zygodactylous z' were also significantly reduced in frequency.General findings with respect to the soles of patients with X, XXX, XXY, and XYY sex chromosomal abnormalities are also reviewed. Discrepancies are apparent and further studies are needed.Finally, a dictionary (Appendices 1 and 2) is provided which gives the frequencies ofthe complete pattern configurations on the palms and soles of XXX females.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.