Introduction: In neutropenic patients bacterial and fungal infections are a major cause of morbidity and mortality, especially in hematological malignancies and post-hematopoietic stem cell transplantation. We present here a single institution experience with the use of granulocyte transfusions in children with severe neutropenic sepsis. Material and methods: This is a retrospective analysis of 48 children who received a total of 120 granulocyte transfusions following mobilization with colony-stimulating growth factor (G-CSF) and dexamethasone. Results: Favorable response was seen in 41.6% of the children without any major adverse effects in donor or recipient. Conclusion and clinical significance: Granulocyte transfusions hence may be a useful adjunct to antimicrobials and growth factors in neutropenic sepsis refractory to conventional antimicrobials.
Iron deficiency anaemia (IDA) is the most common haematological disorder seen in childhood. While poor intake of iron is the most common cause of IDA, a diligent search must be made to exclude other causes. We present a 5 year old girl who had recurrent hospital admissions for chest infection, radiographic evidence of bilateral pulmonary infiltrates and severe IDA. When she failed to respond to repeated courses of antibiotics, anti tubercular and parenteral and oral iron therapy, a lung biopsy was done which revealed blood and hemosiderophages within the alveoli. Further investigations were suggestive of SLE (dsDNA positivity). A diagnosis of SLE induced alveolar haemorrhage was made and therapy with glucocorticoids was initiated. She has responded well to therapy.
not only worried about this fatal communicable virus but also other difficulties that are being declared by the patients.One such deadly problem being reported in patients in India in current times, who have produced positive result for COVID-19 and are slowly regaining health, is a fungal disease called mucormycotic or black fungus. With many such cases being announced incities and states like Mumbai Bengaluru, Delhi, and Gujarat it has provoked an extra wave of fear among the general population.Mucormycosis, previouslycalledaszygomycosis, is an uncommon fungal infection. It is caused by the mould related to mucorales, that is found mainly in decayed wood organic matters soil and leaves. They can cause blackening of skin, redness, inflammation,sores and can encroach the eyes, lungs and even the brain, substantiating to be dangerous if left without treatment. So, it is necessary to knowthe etiological factors and prominent symptoms associated withclinical implications of mucormycosismainly invasiveness and perforation into deeper part of the bone.That is why it is necessary to identify immediately any possible badsigns of mucormycosisarising in both, COVID-19 patients, and other individuals. The report must be communicated to the healthcare workerswithout delay so that treatment can be provided at a suitable time and the patient recovers completely.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.