Electrochemical behaviour of anticancer drug zileuton was investigated by direct current polarography (DCP) and differential pulse polarography using a dropping mercury electrode (DME) as working electrode and Ag/AgCl reference electrode in universal buffer of pH range from 2.0 to 12.0. The drug was extracted from the dosage forms in dimethyl formamide (DMF). Kinetic parameters such as diffusion co-efficient (D) and heterogeneous forward rate constants (k0f,h) are evaluated and reported. The differential pulse polarographic method has been developed for the determination of this drug in pharmaceutical formulations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.