Zoanthamine 1 when treated with H 2 /Pd-C in EtOH yielded dihydrozoanthamine 2 and on treatment with NaBH 4 in dry dichloromethane yielded deoxyzoanthamine 3 and deoxytetrahydrozoanthamine 4 The structures of 2,3 and 4 were determined on the basis of spectral studies. Compounds !, 2, 3 and 4 were tested for their antimicrobial activity.Unusual biosynthetic alkaloids of the class zoanthamine (1,2) have been increasingly becoming important because of their biological activities (3,4,5). In continuation of our search for biologically active molecules from marine organisms (6,7), we isolated zoanthamine I as major constituent from unidentified colonial zoanthid of the genus Zoanthus We report herein the preparation of zoanthamine reduced analogues and evaluation of their antimicrobial activity.

A series of novel 2-amino 3-cyano 4-aryl pyrano[2,3H]chrysin derivatives (3a-m) were efficiently synthesized by one-pot three-component reaction of aromatic aldehydes, malononitrile and chrysin and characterized by 1 H NMR, 13 C NMR and mass spectral data. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity (antibacterial and antifungal). Among the tested compounds, 3a, 3g, 3h, 3j and 3k showed potent antibacterial activity compared to ciprofloxacin and the compounds 3a, 3g, 3h, 3i and 3k showed excellent antifungal activity compared to itrazole. The compounds 3a, 3g, 3h and 3k exhibited potent antimicrobial activity against all the selected pathogenic bacteria and fungi and emerged as potential molecules for further development. In addition, molecular modeling studies also performed to delineate the putative binding mode of these compounds. All of these chrysin derivatives (3a-m) obeyed the Lipinski's ''rule of five'' and have drug-likeness. Docking scores with appreciable binding energy values also exactly correlated with the experimental antimicrobial activity. The chemscore estimated by GOLD software was found to have a good correlation with the experimental inhibitory activity. Graphical Abstract Docking of compound 3g with protein A series of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives (3a-m) has been synthesized and evaluated for their antimicrobial activity along with molecular modeling studies

No abstract

No abstract

No abstract