Highlights d Periostin induces itch behavior in mice, dogs, and nonhuman primates d Periostin directly activates sensory neurons through its integrin a V b3 receptor d TSLP induces the secretion of periostin in keratinocytes via the JAK/STAT pathway d A TSLP-periostin mutual activation loop might be involved in chronic allergic itch
Fig. 1. (A) Double in situ hybridization (ISH) reveals that the neuropeptide natriuretic polypeptide b (NPPB) (green) co-expresses interleukin (IL)-31receptor (red). (B) Double ISH of IL-31Ra co-expresses oncostatin M receptor (OSMR). (C) Itch responses to subcutaneously injected IL-31 (1.5 nmol) were significantly attenuated in NPPB knockout mice and mice treated with NPPB-saporin. (D) No differences in itch responses were observed in mice lacking B-and T-cell receptors (NOD/SCID) compare to control mice (NOD). Itch behaviors were observed in mice within 30 min of administering IL-31. Each column represents the mean ± SEM, n ≥ 6 mice for each group, **p < 0.01.
Highlights d Periostin induces itch behavior in mice, dogs, and nonhuman primates d Periostin directly activates sensory neurons through its integrin a V b3 receptor d TSLP induces the secretion of periostin in keratinocytes via the JAK/STAT pathway d A TSLP-periostin mutual activation loop might be involved in chronic allergic itch
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