The skeleton of lucidumone was constructed through oxidative dearomatization/intramolecular Diels−Alder reaction, Cu-mediated remote C−H hydroxylation, allyl oxidation, acid-promoted dynamic kinetic resolution cyclization, and benzylic oxidation.M eroterpenoids are important natural products and widely present in plants and fungi. So far, many meroterpenoids have been isolated. Among these natural products, meroterpenoids isolated from fungi mainly have complex diverse structures and potent biological characteristics, which have attracted a great deal of attention from the pharmacological and synthetic communities. 1 So far, many kinds of meroterpenoids have been isolated from Ganoderma mushrooms, bearing complex structures and potent biological activities. 2 Recently, several Ganoderma meroterpenoids were isolated, including lingzhiol, 3 applanatumol C, 4 sinensilactam A, 5 applanatumol B, 6 and cochlearol A 7 (Figure 1).In 2019, a novel meroterpenoid named lucidumone was isolated from the fruiting bodies of Ganoderma lucidum. 8 Related investigations showed that it can selectively inhibit COX-2 via binding to Tyr385. 9
The P-wave charm-strange mesons Ds0(2317) and Ds1(2460) lie below the DK and D * K threshold respectively. They are extremely narrow because their strong decays violate the isospin symmetry. We study the possible heavy molecular states composed of a pair of excited charm strange mesons. As a byproduct, we also present the numerical results for the bottonium-like analogue.
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