Based on these findings, the addition of two new symptoms (loss of appetite and weight) to the GSI is proposed in order to increase the test's sensitivity. However, the addition of urinary symptoms to the GSI requires further validation.
Purpose:
To study the role of statin therapy on diabetic retinopathy (DR) progression.
Methods:
This retrospective study was carried out at a tertiary care hospital in southern India. Data were collected from the medical records of patients admitted from January 2013 to December 2018. Out of 1673 patients of DR enrolled in the study, 171 met the inclusion criteria. Patients' demographic data, drug history, clinical characteristics, and laboratory investigations were recorded as per the pro forma. The patients were divided into statin users and nonusers. The results were analyzed to compare the DR progression between the two groups.
Results:
DR progressed in 67% of nonstatin users and 37% of statin users (
P
< 0.001). The use of statins decreased the risk of DR progression (
P
< 0.001). Center-involving macular edema was seen in 8 of 79 statin users (10%) and 16 of 92 statin nonusers (16%) based on optical coherence tomography findings during the follow-up period (
P
= 0.17).
Conclusion:
In patients with type 2 diabetes, lipid-lowering therapy with statins has the potential to retard DR progression.
Aim: To investigate the antiepileptic activity of vortioxetine. Materials and method: Vortioxetine was screened for its antiepileptic activity in Sprague-Dawley rats using maximal electroshock model. 4 groups of rats (each 6 rats) were used. First group was administered distilled water, second group diazepam and the third and fourth groups were given vortioxetine 10mg/kg and 20mg/kg respectively. These drug were given 30 minutes before the animal was subjected to electroshock (150mA, 50Hz for 0.2 seconds). Results: Vortioxetine effectively reduced tonic hind limb extension (THLE) in the rats and the effect was statistically significant compared to the control group. The seizure duration was also significantly lower compared to the control. There was no substantial difference in the duration of seizures and THLE between the diazepam and vortioxetine group. However, the total seizure score of the vortioxetine group was not statistically significant compared to the control group. Conclusion: Vortioxetine has the potential to be clinically useful in treating epilepsy. Further detailed studies using other animal models and in humans are required to prove its efficacy in epilepsy.
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