Aim: The present study was aimed to design and optimize colon-targeted drug delivery system of budesonide for the treatment of asthma. Materials and Methods: The system consists of formaldehyde-treated insoluble hard gelatin capsule body filled with budesonide-sustained release granules prepared with different polymers of HPMCK 4 M, Eudragit L 100 , and ethyl cellulose 20 cps. A response surface methodology based on central composite design was employed to investigate the influence of the amount of HPMCK 15 M (hydrogel plug) and KCl (osmogen) on the lag time and percent drug release. Results and Discussion: The optimized formulation (P 9) containing budesonide-sustained release granules of 120 mg, hydrogel plug of 100 mg, and osmogen of 80 mg, and formulation was prepared according to software determined levels. Both hydrogel plug and osmogen had a significant influence on the lag time and percent drug release. In vivo X-ray imaging study confirmed that the coated capsules dissolved at the targeted colon region. Conclusion: The present pulsincap formulation was effective in providing colon-targeted drug release after predetermined lag time.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.