These studies were undertaken to evaluate in humans the possible physiological role of prostaglandins of the E series (PGE) in modulating insulin release and to assess whether endogenous PGE synthesis may account for the biphasic pattern of insulin secretion. We used a square-wave glucose stimulation previously determined to give maximal biphasic insulin release. Infusion of lysine acetylsalicylate to block the synthesis of endogenous PGE increased by twofold total insulin response to glucose and also converted insulin release to a multiphasic pattern. The infusion of exogenous PGE1 (0.2 microgram X kg-1 X min-1) or PGE2 (10 micrograms/min) in addition to lysine acetylsalicylate restored the typical biphasic pattern of insulin release and also decreased total insulin release to values similar to those of control studies. Infusion of either PGE1 or PGE2 in the absence of lysine acetylsalicylate reset insulin secretion to a lower level without altering the kinetics of release. On the basis of these results, it is hypothesized that endogenous PGE released in response to glucose stimulation exert an inhibiting effect on insulin release that becomes biphasic in appearance.
A three-parameters model for the interpolation of fatigue crack propagation data is proposed. It
has been validated by a Literature data set obtained by testing 180 M(T) specimens under three different loading
levels. In details, it is highlighted that the results of the analysis carried out by means of the proposed model are
more smooth and clear than those obtainable using other methods or models. Also, the parameters of the
model have been computed and some peculiarities have been picked out
This large cross-sectional study suggests that postmenopausal women are at higher risk of type 2 diabetes after allowance for the effect of age. Other main determinants of risk of type 2 diabetes in women around menopause were low socioeconomic status and being overweight. Diabetes was found less frequently in those taking hormone replacement therapy.
Several studies have been carried out until now by various Research Agencies and Railway\ud
Administrations to quantify the effects of the track-bed geometrical characteristics on the transverse strength of\ud
the track. Unfortunately, not all the possible scenarios in terms of track components, track-bed cross profile,\ud
operating conditions etc. have been investigated and not all the relevant variables have been directly measured.\ud
Therefore data available from the literature have different degrees of reliability.\ud
With the aim of enlarging the knowledge on the track stability and covering much of the possible relevant\ud
scenarios, an experimental research program has been developed in the framework of a cooperation between\ud
RFI, Italcertifer and DII.\ud
In order to perform the investigation under quite general conditions and to reduce the experimentation costs, n.\ud
28 significant scenarios have been identified and reproduced on as many independent track segments. By\ud
applying on each track segment a transversal load, the strength of the ballast-sleeper interface has been\ud
determined. The results relative to the first four scenarios are presented in terms of applied load vs. lateral track\ud
displacement diagrams and in more synthetic numerical tables
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