This paper deals with a computer assisted method for a quantitative evaluation of cholesterol plaques in histological cross sections of blood vessels. The demonstrated system automatically specifies several characteristic parameters of the extention of the plaque. These measures are suitable for controling therapeutic interventions. The different steps of digital image processing are discussed. Furthermore a 3D-reconsauction of different parts of the vessel can be obtained if a lot of adjacent slices are taken into consideration. This optional presentation enables a much more better understanding of the atherosclerotic process in the true geometry of the vessel. A userfriendly interface allows rotating of the reconstructed vessels, zooming and windowing of three different objects simultaneously.
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