A comparative study of the ultrastructural changes in rat pulmonary vessels was made in two different situtations of increased vascular permeability: one caused by alpha-naphthylthiourea (ANTU) and the other induced by ammonium sulphate (AS). AS had a more destructive effect on the capillaries but showed little alteration in vessels larger than capillaries. ANTU provoked milder ultrastructural lesions but acted on capillaries, arterial and venous structures. In both conditions intravenously injected carbon particles adhered to the vessel wall and leakage into the interstitial space was rarely seen despite the presence of endothelial gaps. It was concluded that ANTU and AS provoke different ultrastructural alterations and that pulmonary and systemic vessels react differently when undergoing changes in permeability.
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
By means of the colloidal carbon technique and injection of a barium-gelatin mixture into the pulmonary artery, the ultrastructure of lung arterioles in a state of increased permeability has been studied. In certain conditions pulmonary arteriolar permeability changes are frequent and the carbon particles adhere to the endothelium. Leakage of carbon into the interstitial space is observed only rarely. It is concluded that the pulmonary and systemic vessels have different patterns of response to altered permeability.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.