A new optically active diterpene lactone, sinulariolone [1], has been isolated as the major secondary metabolite in a Philippine collection of Sinularia flexihilis. The compound has a tricyclic structure and is more highly oxygenated than previously reported diterpenes from this species. The structure of 1 was elucidated by spectroscopy and its relative stereochemistry confirmed by single-crystal X-ray crystallography.

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